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Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe

BACKGROUND: Absolute temperature measurements of tissues inside the human body are difficult to perform non-invasively. Yet, for brown adipose tissue (BAT), these measurements would enable direct monitoring of its thermogenic activity and its association with metabolic health. METHODS: Here, we repo...

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Autores principales: Zhang, Le, Antonacci, Michael, Burant, Alex, McCallister, Andrew, Kelley, Michele, Bryden, Nicholas, McHugh, Christian, Atalla, Sebastian, Holmes, Leah, Katz, Laurence, Branca, Rosa Tamara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582175/
https://www.ncbi.nlm.nih.gov/pubmed/37848608
http://dx.doi.org/10.1038/s43856-023-00374-x
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author Zhang, Le
Antonacci, Michael
Burant, Alex
McCallister, Andrew
Kelley, Michele
Bryden, Nicholas
McHugh, Christian
Atalla, Sebastian
Holmes, Leah
Katz, Laurence
Branca, Rosa Tamara
author_facet Zhang, Le
Antonacci, Michael
Burant, Alex
McCallister, Andrew
Kelley, Michele
Bryden, Nicholas
McHugh, Christian
Atalla, Sebastian
Holmes, Leah
Katz, Laurence
Branca, Rosa Tamara
author_sort Zhang, Le
collection PubMed
description BACKGROUND: Absolute temperature measurements of tissues inside the human body are difficult to perform non-invasively. Yet, for brown adipose tissue (BAT), these measurements would enable direct monitoring of its thermogenic activity and its association with metabolic health. METHODS: Here, we report direct measurement of absolute BAT temperature in humans during cold exposure by magnetic resonance (MR) with laser polarized xenon gas. This methodology, which leverages on the sensitivity of the chemical shift of the (129)Xe isotope to temperature-induced changes in fat density, is first calibrated in vitro and then tested in vivo in rodents. Finally, it is used in humans along with positron emission tomography (PET) scans with fluorine-18-fluorodeoxyglucose to detect BAT thermogenic activity during cold exposure. RESULTS: Absolute temperature measurements, obtained in rodents with an experimental error of 0.5 °C, show only a median deviation of 0.12 °C against temperature measurements made using a pre-calibrated optical temperature probe. In humans, enhanced uptake of (129)Xe in BAT during cold exposure leads to background-free detection of this tissue by MR. Global measurements of supraclavicular BAT temperature, made over the course of four seconds and with an experimental error ranging from a minimum of 0.4 °C to more than 2 °C, in case of poor shimming, reveal an average BAT temperature of 38.8° ± 0.8 °C, significantly higher (p < 0.02 two-sided t test) than 37.7 °C. Hot BAT is also detected in participants with a PET scan negative for BAT. CONCLUSIONS: Non-invasive, radiation-free measurements of BAT temperature by MRI with hyperpolarized (129)Xe may enable longitudinal monitoring of human BAT activity under various stimulatory conditions.
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spelling pubmed-105821752023-10-19 Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe Zhang, Le Antonacci, Michael Burant, Alex McCallister, Andrew Kelley, Michele Bryden, Nicholas McHugh, Christian Atalla, Sebastian Holmes, Leah Katz, Laurence Branca, Rosa Tamara Commun Med (Lond) Article BACKGROUND: Absolute temperature measurements of tissues inside the human body are difficult to perform non-invasively. Yet, for brown adipose tissue (BAT), these measurements would enable direct monitoring of its thermogenic activity and its association with metabolic health. METHODS: Here, we report direct measurement of absolute BAT temperature in humans during cold exposure by magnetic resonance (MR) with laser polarized xenon gas. This methodology, which leverages on the sensitivity of the chemical shift of the (129)Xe isotope to temperature-induced changes in fat density, is first calibrated in vitro and then tested in vivo in rodents. Finally, it is used in humans along with positron emission tomography (PET) scans with fluorine-18-fluorodeoxyglucose to detect BAT thermogenic activity during cold exposure. RESULTS: Absolute temperature measurements, obtained in rodents with an experimental error of 0.5 °C, show only a median deviation of 0.12 °C against temperature measurements made using a pre-calibrated optical temperature probe. In humans, enhanced uptake of (129)Xe in BAT during cold exposure leads to background-free detection of this tissue by MR. Global measurements of supraclavicular BAT temperature, made over the course of four seconds and with an experimental error ranging from a minimum of 0.4 °C to more than 2 °C, in case of poor shimming, reveal an average BAT temperature of 38.8° ± 0.8 °C, significantly higher (p < 0.02 two-sided t test) than 37.7 °C. Hot BAT is also detected in participants with a PET scan negative for BAT. CONCLUSIONS: Non-invasive, radiation-free measurements of BAT temperature by MRI with hyperpolarized (129)Xe may enable longitudinal monitoring of human BAT activity under various stimulatory conditions. Nature Publishing Group UK 2023-10-17 /pmc/articles/PMC10582175/ /pubmed/37848608 http://dx.doi.org/10.1038/s43856-023-00374-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Le
Antonacci, Michael
Burant, Alex
McCallister, Andrew
Kelley, Michele
Bryden, Nicholas
McHugh, Christian
Atalla, Sebastian
Holmes, Leah
Katz, Laurence
Branca, Rosa Tamara
Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe
title Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe
title_full Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe
title_fullStr Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe
title_full_unstemmed Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe
title_short Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)Xe
title_sort absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized (129)xe
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582175/
https://www.ncbi.nlm.nih.gov/pubmed/37848608
http://dx.doi.org/10.1038/s43856-023-00374-x
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