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A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran
Reliable obstructive sleep apnea (OSA) prevalence information in Iran is lacking due to inconsistent local study results. To estimate OSA prevalence and identify clinical phenotypes, we conducted a nationally representative study using multi-stage random cluster sampling. We recruited 3198 individua...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582253/ https://www.ncbi.nlm.nih.gov/pubmed/37848453 http://dx.doi.org/10.1038/s41598-023-44229-w |
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author | Sadeghniiat-Haghighi, Khosro Akbarpour, Samaneh Behkar, Atefeh Moradzadeh, Rahmatollah Alemohammad, Zahra Banafsheh Forouzan, Nazanin Mouseli, Ali Amirifard, Hamed Najafi, Arezu |
author_facet | Sadeghniiat-Haghighi, Khosro Akbarpour, Samaneh Behkar, Atefeh Moradzadeh, Rahmatollah Alemohammad, Zahra Banafsheh Forouzan, Nazanin Mouseli, Ali Amirifard, Hamed Najafi, Arezu |
author_sort | Sadeghniiat-Haghighi, Khosro |
collection | PubMed |
description | Reliable obstructive sleep apnea (OSA) prevalence information in Iran is lacking due to inconsistent local study results. To estimate OSA prevalence and identify clinical phenotypes, we conducted a nationally representative study using multi-stage random cluster sampling. We recruited 3198 individuals and extrapolated the results to the entire Iranian population using complex sample survey analyses. We identified 3 clinical phenotypes as “sleepy,” “insomnia,” and “restless legs syndrome (RLS).” The prevalence of OSA was 28.7% (95%CI: 26.8–30.6). The prevalence of “sleepy,” “insomnia,” and “RLS” phenotypes were 82.3%, 77.8%, and 36.5% in women, and 64.8%, 67.5%, and 17.9% in men, respectively. “Sleepy” and “insomnia” phenotypes overlapped the most. Age (OR: 1.9), male sex (OR: 3.8), BMI (OR: 1.13), neck circumference (OR: 1.3), RLS (OR: 2.0), and insomnia (OR: 2.3) were significant OSA predictors (p-values: 0.001). In men, “sleepy” phenotype was associated with youth and unmarried status but not in women. The “insomnia” phenotype was associated with shorter sleep duration in women; cardiovascular diseases (CVD), urban residency, and shorter sleep duration in men. “RLS” phenotype was associated with shorter sleep duration and CVD in women and older age, lower educational level, CVD, and hypertension in men. The findings point to the need for funding of OSA screening in Iran, for a different assessment of men and women, and for future sleep research to consider overlapping phenotypes. |
format | Online Article Text |
id | pubmed-10582253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105822532023-10-19 A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran Sadeghniiat-Haghighi, Khosro Akbarpour, Samaneh Behkar, Atefeh Moradzadeh, Rahmatollah Alemohammad, Zahra Banafsheh Forouzan, Nazanin Mouseli, Ali Amirifard, Hamed Najafi, Arezu Sci Rep Article Reliable obstructive sleep apnea (OSA) prevalence information in Iran is lacking due to inconsistent local study results. To estimate OSA prevalence and identify clinical phenotypes, we conducted a nationally representative study using multi-stage random cluster sampling. We recruited 3198 individuals and extrapolated the results to the entire Iranian population using complex sample survey analyses. We identified 3 clinical phenotypes as “sleepy,” “insomnia,” and “restless legs syndrome (RLS).” The prevalence of OSA was 28.7% (95%CI: 26.8–30.6). The prevalence of “sleepy,” “insomnia,” and “RLS” phenotypes were 82.3%, 77.8%, and 36.5% in women, and 64.8%, 67.5%, and 17.9% in men, respectively. “Sleepy” and “insomnia” phenotypes overlapped the most. Age (OR: 1.9), male sex (OR: 3.8), BMI (OR: 1.13), neck circumference (OR: 1.3), RLS (OR: 2.0), and insomnia (OR: 2.3) were significant OSA predictors (p-values: 0.001). In men, “sleepy” phenotype was associated with youth and unmarried status but not in women. The “insomnia” phenotype was associated with shorter sleep duration in women; cardiovascular diseases (CVD), urban residency, and shorter sleep duration in men. “RLS” phenotype was associated with shorter sleep duration and CVD in women and older age, lower educational level, CVD, and hypertension in men. The findings point to the need for funding of OSA screening in Iran, for a different assessment of men and women, and for future sleep research to consider overlapping phenotypes. Nature Publishing Group UK 2023-10-17 /pmc/articles/PMC10582253/ /pubmed/37848453 http://dx.doi.org/10.1038/s41598-023-44229-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sadeghniiat-Haghighi, Khosro Akbarpour, Samaneh Behkar, Atefeh Moradzadeh, Rahmatollah Alemohammad, Zahra Banafsheh Forouzan, Nazanin Mouseli, Ali Amirifard, Hamed Najafi, Arezu A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran |
title | A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran |
title_full | A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran |
title_fullStr | A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran |
title_full_unstemmed | A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran |
title_short | A nationwide study on the prevalence and contributing factors of obstructive sleep apnea in Iran |
title_sort | nationwide study on the prevalence and contributing factors of obstructive sleep apnea in iran |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582253/ https://www.ncbi.nlm.nih.gov/pubmed/37848453 http://dx.doi.org/10.1038/s41598-023-44229-w |
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