Uptake of long-chain fatty acids from the bone marrow suppresses CD8(+) T-cell metabolism and function in multiple myeloma

T cells demonstrate impaired function in multiple myeloma (MM) but suppressive mechanisms in the bone marrow microenvironment remain poorly defined. We observe that bone marrow CD8(+) T-cell function is decreased in MM compared with controls, and is also consistently lower within bone marrow samples...

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Detalles Bibliográficos
Autores principales: Gudgeon, Nancy, Giles, Hannah, Bishop, Emma L., Fulton-Ward, Taylor, Escribano-Gonzalez, Cristina, Munford, Haydn, James-Bott, Anna, Foster, Kane, Karim, Farheen, Jayawardana, Dedunu, Mahmood, Ansar, Cribbs, Adam P., Tennant, Daniel A., Basu, Supratik, Pratt, Guy, Dimeloe, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582277/
https://www.ncbi.nlm.nih.gov/pubmed/37276076
http://dx.doi.org/10.1182/bloodadvances.2023009890

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