Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature

Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered,...

Descripción completa

Detalles Bibliográficos
Autores principales: Porragas-Paseiro, Hector S., Johnson, Steven, Brubaker, Lindsay, Sanders, Brooke E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582284/
https://www.ncbi.nlm.nih.gov/pubmed/37860081
http://dx.doi.org/10.1016/j.gore.2023.101286
_version_ 1785122295315955712
author Porragas-Paseiro, Hector S.
Johnson, Steven
Brubaker, Lindsay
Sanders, Brooke E.
author_facet Porragas-Paseiro, Hector S.
Johnson, Steven
Brubaker, Lindsay
Sanders, Brooke E.
author_sort Porragas-Paseiro, Hector S.
collection PubMed
description Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered, and ultimately completed consolidation treatment for GTN on single agent MTX. While MTX administration is associated with an increased risk of PJP, this association is best described in rheumatology literature. This is the first case of PJP complicating MTX therapy within the gynecologic oncology literature.
format Online
Article
Text
id pubmed-10582284
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105822842023-10-19 Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature Porragas-Paseiro, Hector S. Johnson, Steven Brubaker, Lindsay Sanders, Brooke E. Gynecol Oncol Rep Case Report Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered, and ultimately completed consolidation treatment for GTN on single agent MTX. While MTX administration is associated with an increased risk of PJP, this association is best described in rheumatology literature. This is the first case of PJP complicating MTX therapy within the gynecologic oncology literature. Elsevier 2023-10-09 /pmc/articles/PMC10582284/ /pubmed/37860081 http://dx.doi.org/10.1016/j.gore.2023.101286 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Porragas-Paseiro, Hector S.
Johnson, Steven
Brubaker, Lindsay
Sanders, Brooke E.
Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature
title Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature
title_full Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature
title_fullStr Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature
title_full_unstemmed Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature
title_short Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature
title_sort pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582284/
https://www.ncbi.nlm.nih.gov/pubmed/37860081
http://dx.doi.org/10.1016/j.gore.2023.101286
work_keys_str_mv AT porragaspaseirohectors pneumocystisjiroveciipneumoniacomplicatingmethotrexatetreatmentinapatientwithlowriskpostmolargestationaltrophoblasticneoplasiaacasereportandreviewoftheliterature
AT johnsonsteven pneumocystisjiroveciipneumoniacomplicatingmethotrexatetreatmentinapatientwithlowriskpostmolargestationaltrophoblasticneoplasiaacasereportandreviewoftheliterature
AT brubakerlindsay pneumocystisjiroveciipneumoniacomplicatingmethotrexatetreatmentinapatientwithlowriskpostmolargestationaltrophoblasticneoplasiaacasereportandreviewoftheliterature
AT sandersbrookee pneumocystisjiroveciipneumoniacomplicatingmethotrexatetreatmentinapatientwithlowriskpostmolargestationaltrophoblasticneoplasiaacasereportandreviewoftheliterature

Ejemplares similares