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Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline

Background: A new, effective anti-tuberculosis (TB) regimen containing bedaquiline (BDQ) and pyrifazimine (TBI-166) has been recommended for a phase IIb clinical trial. Preclinical drug–drug interaction (DDI) studies of the combination of BDQ and TBI-166 have been designed to support future clinical...

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Detalles Bibliográficos
Autores principales:	Ding, Yangming, Liu, Haiting, Wang, Furun, Fu, Lei, Zhu, Hui, Fu, Shuang, Wang, Ning, Zhuang, Xiaomei, Lu, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582325/ https://www.ncbi.nlm.nih.gov/pubmed/37860115 http://dx.doi.org/10.3389/fphar.2023.1154780

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