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Small interfering RNA–mediated allele-selective silencing of von Willebrand factor in vitro and in vivo

An imbalance in von Willebrand factor (VWF) may either lead to bleeding (von Willebrand disease, VWD) or thrombosis. Both disorders have shortcomings in the currently available treatments. VWF itself could be a potential therapeutic target because of its role in both bleeding and thrombosis. Inhibit...

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Detalles Bibliográficos
Autores principales:	Jongejan, Yvonne K., Schrader Echeverri, Elisa, Dirven, Richard J., Paunovska, Kalina, Linthorst, Noa A., de Jong, Annika, Wellershoff, Johannes C., van der Gouw, Kim D., van Vlijmen, Bart J. M., Dahlman, James E., Eikenboom, Jeroen C. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582391/ https://www.ncbi.nlm.nih.gov/pubmed/37467023 http://dx.doi.org/10.1182/bloodadvances.2023010643

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