Alzheimer's Progenitor Amyloid‐β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function (Adv. Sci. 29/2023)

Amyloid‐β Amyloid‐β (Aβ) is a neuropeptide whose aggregation leads to dementia. In article number 2301423, Daniel E. Otzen, Thomas Paul Davis, Ibrahim Javed, and co‐workers have discovered an anti‐biofilm role of Aβ where Aβ monomers target and destroy the microbial biofilms. This indicates a physio...

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Detalles Bibliográficos
Autores principales: Ali, Syed Aoun, Chung, Ka Hang Karen, Forgham, Helen, Olsen, William P., Kakinen, Aleksandr, Balaji, Arunpandian, Otzen, Daniel E., Davis, Thomas Paul, Javed, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582403/
http://dx.doi.org/10.1002/advs.202370200
Descripción
Sumario:Amyloid‐β Amyloid‐β (Aβ) is a neuropeptide whose aggregation leads to dementia. In article number 2301423, Daniel E. Otzen, Thomas Paul Davis, Ibrahim Javed, and co‐workers have discovered an anti‐biofilm role of Aβ where Aβ monomers target and destroy the microbial biofilms. This indicates a physiological role of Aβ as brain's defence system against local and distal microbial infections. [Image: see text]

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