Cargando…
Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture
Common biliary tract is ≈4 mm in diameter to deliver bile from liver to small intestine to help digestion. The abnormal narrowing leads to severe symptoms such as pain and nausea. Stents are an effective treatment. Compared with non‐degradable stents which require repeated removal, biodegradable ste...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582434/ https://www.ncbi.nlm.nih.gov/pubmed/37552006 http://dx.doi.org/10.1002/advs.202303779 |
_version_ | 1785122330147553280 |
---|---|
author | Wang, Wei Luan, Zhaohui Shu, Zhenzhen Xu, Kaige Wang, Tongchuan Liu, Shuang Wu, Xiaozhuo Liu, Hangzong Ye, Shaosong Dan, Ruijue Zhao, Xiaoyan Yang, Shiming Xing, Malcolm Fan, Chaoqiang |
author_facet | Wang, Wei Luan, Zhaohui Shu, Zhenzhen Xu, Kaige Wang, Tongchuan Liu, Shuang Wu, Xiaozhuo Liu, Hangzong Ye, Shaosong Dan, Ruijue Zhao, Xiaoyan Yang, Shiming Xing, Malcolm Fan, Chaoqiang |
author_sort | Wang, Wei |
collection | PubMed |
description | Common biliary tract is ≈4 mm in diameter to deliver bile from liver to small intestine to help digestion. The abnormal narrowing leads to severe symptoms such as pain and nausea. Stents are an effective treatment. Compared with non‐degradable stents which require repeated removal, biodegradable stents have the advantage of reducing secondary injury related to endoscopic operation and patient burden. However, current biodegradable materials may cause tissue hyperplasia and the treatment method does not target etiology of stricture. So recurrence rates after biodegradable stent implantation are still high. Here, a biodegradable helical stent fabricated from biosynthetic P(3HB‐co‐4HB) is reported. Tunable properties can be acquired through altering culture substrates. Stent shows shape memory in various solvents. The stent has an optimized design with helical structure and outer track. The self‐expanding of helical structure and double drainage realized by outer track greatly improve drainage of bile. Importantly, stent‐loading triamcinolone acetonide can inhibit proliferation of fibroblasts and reduce incidence of restricture. Therapeutic effect is also demonstrated in minipigs with biliary stricture. The results of minipig experiments show that biliary duct in treatment group is unobstructed and tissue hyperplasia is effectively inhibited. |
format | Online Article Text |
id | pubmed-10582434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105824342023-10-19 Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture Wang, Wei Luan, Zhaohui Shu, Zhenzhen Xu, Kaige Wang, Tongchuan Liu, Shuang Wu, Xiaozhuo Liu, Hangzong Ye, Shaosong Dan, Ruijue Zhao, Xiaoyan Yang, Shiming Xing, Malcolm Fan, Chaoqiang Adv Sci (Weinh) Research Articles Common biliary tract is ≈4 mm in diameter to deliver bile from liver to small intestine to help digestion. The abnormal narrowing leads to severe symptoms such as pain and nausea. Stents are an effective treatment. Compared with non‐degradable stents which require repeated removal, biodegradable stents have the advantage of reducing secondary injury related to endoscopic operation and patient burden. However, current biodegradable materials may cause tissue hyperplasia and the treatment method does not target etiology of stricture. So recurrence rates after biodegradable stent implantation are still high. Here, a biodegradable helical stent fabricated from biosynthetic P(3HB‐co‐4HB) is reported. Tunable properties can be acquired through altering culture substrates. Stent shows shape memory in various solvents. The stent has an optimized design with helical structure and outer track. The self‐expanding of helical structure and double drainage realized by outer track greatly improve drainage of bile. Importantly, stent‐loading triamcinolone acetonide can inhibit proliferation of fibroblasts and reduce incidence of restricture. Therapeutic effect is also demonstrated in minipigs with biliary stricture. The results of minipig experiments show that biliary duct in treatment group is unobstructed and tissue hyperplasia is effectively inhibited. John Wiley and Sons Inc. 2023-08-08 /pmc/articles/PMC10582434/ /pubmed/37552006 http://dx.doi.org/10.1002/advs.202303779 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Wang, Wei Luan, Zhaohui Shu, Zhenzhen Xu, Kaige Wang, Tongchuan Liu, Shuang Wu, Xiaozhuo Liu, Hangzong Ye, Shaosong Dan, Ruijue Zhao, Xiaoyan Yang, Shiming Xing, Malcolm Fan, Chaoqiang Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture |
title | Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture |
title_full | Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture |
title_fullStr | Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture |
title_full_unstemmed | Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture |
title_short | Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture |
title_sort | biosynthetic plastics as tunable elastic and visible stent with shape‐memory to treat biliary stricture |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582434/ https://www.ncbi.nlm.nih.gov/pubmed/37552006 http://dx.doi.org/10.1002/advs.202303779 |
work_keys_str_mv | AT wangwei biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT luanzhaohui biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT shuzhenzhen biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT xukaige biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT wangtongchuan biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT liushuang biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT wuxiaozhuo biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT liuhangzong biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT yeshaosong biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT danruijue biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT zhaoxiaoyan biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT yangshiming biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT xingmalcolm biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture AT fanchaoqiang biosyntheticplasticsastunableelasticandvisiblestentwithshapememorytotreatbiliarystricture |