Understanding cancer drug resistance with Sleeping Beauty functional genomic screens: Application to MAPK inhibition in cutaneous melanoma

Combined BRAF and MEK inhibition is an effective treatment for BRAF-mutant cutaneous melanoma. However, most patients progress on this treatment due to drug resistance. Here, we applied the Sleeping Beauty transposon system to understand how melanoma evades MAPK inhibition. We found that the specifi...

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Detalles Bibliográficos
Autores principales: Zhu, Eliot Y., Schillo, Jacob L., Murray, Sarina D., Riordan, Jesse D., Dupuy, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582486/
https://www.ncbi.nlm.nih.gov/pubmed/37860756
http://dx.doi.org/10.1016/j.isci.2023.107805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582486/
https://www.ncbi.nlm.nih.gov/pubmed/37860756
http://dx.doi.org/10.1016/j.isci.2023.107805

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