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Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience
PURPOSE: The detection rate of early-stage lung cancer with ground-glass opacity (GGO) has increased, and stereotactic body radiotherapy (SBRT) has been suggested as an alternative to surgery in inoperable patients. However, reports on treatment results are limited. Therefore, we performed a retrosp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582546/ https://www.ncbi.nlm.nih.gov/pubmed/36960626 http://dx.doi.org/10.4143/crt.2022.1656 |
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author | Jang, Jeong Yun Kim, Su Ssan Song, Si Yeol Shin, Young Seob Lee, Sei Won Ji, Wonjun Choi, Chang-Min Choi, Eun Kyung |
author_facet | Jang, Jeong Yun Kim, Su Ssan Song, Si Yeol Shin, Young Seob Lee, Sei Won Ji, Wonjun Choi, Chang-Min Choi, Eun Kyung |
author_sort | Jang, Jeong Yun |
collection | PubMed |
description | PURPOSE: The detection rate of early-stage lung cancer with ground-glass opacity (GGO) has increased, and stereotactic body radiotherapy (SBRT) has been suggested as an alternative to surgery in inoperable patients. However, reports on treatment results are limited. Therefore, we performed a retrospective study to investigate the clinical outcome after SBRT in patients with early-stage lung cancer with GGO-predominant tumor lesions at a single institution. MATERIALS AND METHODS: This study included 89 patients with 99 lesions who were treated with SBRT for lung cancer with GGO-predominant lesions that had a consolidation-to-tumor ratio of ≤ 0.5 at Asan Medical Center between July 2016 and July 2021. A median total dose of 56.0 Gy (range, 48.0 to 60.0) was delivered using 10.0–15.0 Gy per fraction. RESULTS: The overall follow-up period for the study was median 33.0 months (range, 9.9 to 65.9 months). There was 100% local control with no recurrences in any of the 99 treated lesions. Three patients had regional recurrences outside of the radiation field, and three had distant metastasis. The 1-year, 3-year, and 5-year overall survival rates were 100.0%, 91.6%, and 82.8%, respectively. Univariate analysis revealed that advanced age and a low level of diffusing capacity of the lungs for carbon monoxide were significantly associated with overall survival. There were no patients with grade ≥ 3 toxicity. CONCLUSION: SBRT is a safe and effective treatment for patients with GGO-predominant lung cancer lesions and is likely to be considered as an alternative to surgery. |
format | Online Article Text |
id | pubmed-10582546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-105825462023-10-19 Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience Jang, Jeong Yun Kim, Su Ssan Song, Si Yeol Shin, Young Seob Lee, Sei Won Ji, Wonjun Choi, Chang-Min Choi, Eun Kyung Cancer Res Treat Original Article PURPOSE: The detection rate of early-stage lung cancer with ground-glass opacity (GGO) has increased, and stereotactic body radiotherapy (SBRT) has been suggested as an alternative to surgery in inoperable patients. However, reports on treatment results are limited. Therefore, we performed a retrospective study to investigate the clinical outcome after SBRT in patients with early-stage lung cancer with GGO-predominant tumor lesions at a single institution. MATERIALS AND METHODS: This study included 89 patients with 99 lesions who were treated with SBRT for lung cancer with GGO-predominant lesions that had a consolidation-to-tumor ratio of ≤ 0.5 at Asan Medical Center between July 2016 and July 2021. A median total dose of 56.0 Gy (range, 48.0 to 60.0) was delivered using 10.0–15.0 Gy per fraction. RESULTS: The overall follow-up period for the study was median 33.0 months (range, 9.9 to 65.9 months). There was 100% local control with no recurrences in any of the 99 treated lesions. Three patients had regional recurrences outside of the radiation field, and three had distant metastasis. The 1-year, 3-year, and 5-year overall survival rates were 100.0%, 91.6%, and 82.8%, respectively. Univariate analysis revealed that advanced age and a low level of diffusing capacity of the lungs for carbon monoxide were significantly associated with overall survival. There were no patients with grade ≥ 3 toxicity. CONCLUSION: SBRT is a safe and effective treatment for patients with GGO-predominant lung cancer lesions and is likely to be considered as an alternative to surgery. Korean Cancer Association 2023-10 2023-03-21 /pmc/articles/PMC10582546/ /pubmed/36960626 http://dx.doi.org/10.4143/crt.2022.1656 Text en Copyright © 2023 by the Korean Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jang, Jeong Yun Kim, Su Ssan Song, Si Yeol Shin, Young Seob Lee, Sei Won Ji, Wonjun Choi, Chang-Min Choi, Eun Kyung Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience |
title | Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience |
title_full | Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience |
title_fullStr | Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience |
title_full_unstemmed | Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience |
title_short | Clinical Outcome of Stereotactic Body Radiotherapy in Patients with Early-Stage Lung Cancer with Ground-Glass Opacity Predominant Lesions: A Single Institution Experience |
title_sort | clinical outcome of stereotactic body radiotherapy in patients with early-stage lung cancer with ground-glass opacity predominant lesions: a single institution experience |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582546/ https://www.ncbi.nlm.nih.gov/pubmed/36960626 http://dx.doi.org/10.4143/crt.2022.1656 |
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