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TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort

PURPOSE: Outcome analysis of urachal cancer (UraC) is limited due to the scarcity of cases and different staging methods compared to urothelial bladder cancer (UroBC). We attempted to assess survival outcomes of UraC and compare to UroBC after stage-matched analyses. MATERIALS AND METHODS: Total 203...

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Autores principales: Song, Sang Hun, Lee, Jaewon, Ko, Young Hwii, Kim, Jong Wook, Jung, Seung Il, Kang, Seok Ho, Park, Jinsung, Seo, Ho Kyung, Kim, Hyung Joon, Jeong, Byong Chang, Kim, Tae-Hwan, Choi, Se Young, Nam, Jong Kil, Ku, Ja Yoon, Joo, Kwan Joong, Jang, Won Sik, Yoon, Young Eun, Yun, Seok Joong, Hong, Sung-Hoo, Oh, Jong Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582549/
https://www.ncbi.nlm.nih.gov/pubmed/37080605
http://dx.doi.org/10.4143/crt.2023.417
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author Song, Sang Hun
Lee, Jaewon
Ko, Young Hwii
Kim, Jong Wook
Jung, Seung Il
Kang, Seok Ho
Park, Jinsung
Seo, Ho Kyung
Kim, Hyung Joon
Jeong, Byong Chang
Kim, Tae-Hwan
Choi, Se Young
Nam, Jong Kil
Ku, Ja Yoon
Joo, Kwan Joong
Jang, Won Sik
Yoon, Young Eun
Yun, Seok Joong
Hong, Sung-Hoo
Oh, Jong Jin
author_facet Song, Sang Hun
Lee, Jaewon
Ko, Young Hwii
Kim, Jong Wook
Jung, Seung Il
Kang, Seok Ho
Park, Jinsung
Seo, Ho Kyung
Kim, Hyung Joon
Jeong, Byong Chang
Kim, Tae-Hwan
Choi, Se Young
Nam, Jong Kil
Ku, Ja Yoon
Joo, Kwan Joong
Jang, Won Sik
Yoon, Young Eun
Yun, Seok Joong
Hong, Sung-Hoo
Oh, Jong Jin
author_sort Song, Sang Hun
collection PubMed
description PURPOSE: Outcome analysis of urachal cancer (UraC) is limited due to the scarcity of cases and different staging methods compared to urothelial bladder cancer (UroBC). We attempted to assess survival outcomes of UraC and compare to UroBC after stage-matched analyses. MATERIALS AND METHODS: Total 203 UraC patients from a multicenter database and 373 UroBC patients in single institution from 2000 to 2018 were enrolled (median follow-up, 32 months). Sheldon stage conversion to corresponding TNM staging for UraC was conducted for head-to-head comparison to UroBC. Perioperative clinical variables and pathological results were recorded. Stage-matched analyses for survival by stage were conducted. RESULTS: UraC patients were younger (mean age, 54 vs. 67 years; p < 0.001), with 163 patients (80.3%) receiving partial cystectomy and 23 patients (11.3%) radical cystectomy. UraC was more likely to harbor ≥ pT3a tumors (78.8% vs. 41.8%). While 5-year recurrence-free survival, cancer-specific survival (CSS) and overall survival were comparable between two groups (63.4%, 67%, and 62.1% in UraC and 61.5%, 75.9%, and 67.8% in UroBC, respectively), generally favorable prognosis for UraC in lower stages (pT1–2) but unfavorable outcomes in higher stages (pT4) compared to UroBC was observed, although only 5-year CSS in ≥ pT4 showed statistical significance (p=0.028). Body mass index (hazard ratio [HR], 0.929), diabetes mellitus (HR, 1.921), pathologic T category (HR, 3.846), and lymphovascular invasion (HR, 1.993) were predictors of CSS for all patients. CONCLUSION: Despite differing histology, UraC has comparable prognosis to UroBC with relatively favorable outcome in low stages but worse prognosis in higher stages. The presented system may be useful for future grading and risk stratification of UraC.
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spelling pubmed-105825492023-10-19 TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort Song, Sang Hun Lee, Jaewon Ko, Young Hwii Kim, Jong Wook Jung, Seung Il Kang, Seok Ho Park, Jinsung Seo, Ho Kyung Kim, Hyung Joon Jeong, Byong Chang Kim, Tae-Hwan Choi, Se Young Nam, Jong Kil Ku, Ja Yoon Joo, Kwan Joong Jang, Won Sik Yoon, Young Eun Yun, Seok Joong Hong, Sung-Hoo Oh, Jong Jin Cancer Res Treat Original Article PURPOSE: Outcome analysis of urachal cancer (UraC) is limited due to the scarcity of cases and different staging methods compared to urothelial bladder cancer (UroBC). We attempted to assess survival outcomes of UraC and compare to UroBC after stage-matched analyses. MATERIALS AND METHODS: Total 203 UraC patients from a multicenter database and 373 UroBC patients in single institution from 2000 to 2018 were enrolled (median follow-up, 32 months). Sheldon stage conversion to corresponding TNM staging for UraC was conducted for head-to-head comparison to UroBC. Perioperative clinical variables and pathological results were recorded. Stage-matched analyses for survival by stage were conducted. RESULTS: UraC patients were younger (mean age, 54 vs. 67 years; p < 0.001), with 163 patients (80.3%) receiving partial cystectomy and 23 patients (11.3%) radical cystectomy. UraC was more likely to harbor ≥ pT3a tumors (78.8% vs. 41.8%). While 5-year recurrence-free survival, cancer-specific survival (CSS) and overall survival were comparable between two groups (63.4%, 67%, and 62.1% in UraC and 61.5%, 75.9%, and 67.8% in UroBC, respectively), generally favorable prognosis for UraC in lower stages (pT1–2) but unfavorable outcomes in higher stages (pT4) compared to UroBC was observed, although only 5-year CSS in ≥ pT4 showed statistical significance (p=0.028). Body mass index (hazard ratio [HR], 0.929), diabetes mellitus (HR, 1.921), pathologic T category (HR, 3.846), and lymphovascular invasion (HR, 1.993) were predictors of CSS for all patients. CONCLUSION: Despite differing histology, UraC has comparable prognosis to UroBC with relatively favorable outcome in low stages but worse prognosis in higher stages. The presented system may be useful for future grading and risk stratification of UraC. Korean Cancer Association 2023-10 2023-04-17 /pmc/articles/PMC10582549/ /pubmed/37080605 http://dx.doi.org/10.4143/crt.2023.417 Text en Copyright © 2023 by the Korean Cancer Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Song, Sang Hun
Lee, Jaewon
Ko, Young Hwii
Kim, Jong Wook
Jung, Seung Il
Kang, Seok Ho
Park, Jinsung
Seo, Ho Kyung
Kim, Hyung Joon
Jeong, Byong Chang
Kim, Tae-Hwan
Choi, Se Young
Nam, Jong Kil
Ku, Ja Yoon
Joo, Kwan Joong
Jang, Won Sik
Yoon, Young Eun
Yun, Seok Joong
Hong, Sung-Hoo
Oh, Jong Jin
TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort
title TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort
title_full TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort
title_fullStr TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort
title_full_unstemmed TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort
title_short TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort
title_sort tnm-based head-to-head comparison of urachal carcinoma and urothelial bladder cancer: stage-matched analysis of a large multicenter national cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582549/
https://www.ncbi.nlm.nih.gov/pubmed/37080605
http://dx.doi.org/10.4143/crt.2023.417
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