The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia–reperfusion injury via mitoprotection

BACKGROUND & AIMS: Mitochondrial permeability transition pore (mPTP) opening is critical for mediating cell death during hepatic ischaemia–reperfusion injury (IRI). Blocking mPTP opening by inhibiting cyclophilin D (CypD) is a promising pharmacological approach for the treatment of IRI. Here, we...

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Detalles Bibliográficos
Autores principales: Kheyar, Amel, Ahnou, Nazim, Ahmed-Belkacem, Abdelhakim, Hulin, Anne, Pressiat, Claire, Ghaleh, Bijan, Guichou, Jean-François, Morin, Didier, Pawlotsky, Jean-Michel, Teixeira-Clerc, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582583/
https://www.ncbi.nlm.nih.gov/pubmed/37860051
http://dx.doi.org/10.1016/j.jhepr.2023.100876

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