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Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy
BACKGROUND: Intralesional steroid injection has recently evolved as a novel treatment modality for localized idiopathic granulomatous mastitis (= IGM). We aimed to explore the therapeutic efficacy of local steroid injections (LSI) in patients with severe IGM. METHODS: Fifty-one patients diagnosed wi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582626/ https://www.ncbi.nlm.nih.gov/pubmed/37859855 http://dx.doi.org/10.3389/fmed.2023.1251851 |
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author | Cabioglu, Neslihan Uras, Cihan Mutlu, Halime Sezgin, Derya Emiroglu, Selman Dulgeroglu, Onur Yilmaz, Ravza Tukenmez, Mustafa Arikan, Akif Enes Kara, Halil Muslumanoglu, Mahmut |
author_facet | Cabioglu, Neslihan Uras, Cihan Mutlu, Halime Sezgin, Derya Emiroglu, Selman Dulgeroglu, Onur Yilmaz, Ravza Tukenmez, Mustafa Arikan, Akif Enes Kara, Halil Muslumanoglu, Mahmut |
author_sort | Cabioglu, Neslihan |
collection | PubMed |
description | BACKGROUND: Intralesional steroid injection has recently evolved as a novel treatment modality for localized idiopathic granulomatous mastitis (= IGM). We aimed to explore the therapeutic efficacy of local steroid injections (LSI) in patients with severe IGM. METHODS: Fifty-one patients diagnosed with severe IGM were included in the study and treated with either local steroid injection (LSI) alone (n = 25) or combined LSI with systemic oral steroid treatment (OST) (n = 26). The local steroid injection protocol included an intralesional triamcinolone acetonide injection into the palpable granulomas every 4-week, and topical administration of steroid-containing pomades twice a day on the affected surface of the breast. Patients with a combined LSI and OST received low-dose oral methylprednisolone (<16 mg). RESULTS: Patients with LSI alone required more LSI applications than those in the combined LSI with OST group (LSI: 5 ± 2.9; vs. LSI/OST: 3.5 ± 2.5; p = 0.080) to obtain an effective optimum therapeutic response. At a median of 12 months (range, 4–42), no difference was found in complete response rates between patients in the LSI group and the combined LSI group with OST (52 vs. 53.9%, p = 0.999). However, steroid-related systemic side effects were lower in the LSI alone group (p < 0.008). CONCLUSION: Local steroid injection could be considered as the first-line treatment in patients with severe IGM until a therapeutic response has been obtained either as the sole treatment modality or combined with oral steroids. Compared with systemic oral steroid therapy, local steroid administration can be considered a new treatment modality with fewer side effects. |
format | Online Article Text |
id | pubmed-10582626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105826262023-10-19 Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy Cabioglu, Neslihan Uras, Cihan Mutlu, Halime Sezgin, Derya Emiroglu, Selman Dulgeroglu, Onur Yilmaz, Ravza Tukenmez, Mustafa Arikan, Akif Enes Kara, Halil Muslumanoglu, Mahmut Front Med (Lausanne) Medicine BACKGROUND: Intralesional steroid injection has recently evolved as a novel treatment modality for localized idiopathic granulomatous mastitis (= IGM). We aimed to explore the therapeutic efficacy of local steroid injections (LSI) in patients with severe IGM. METHODS: Fifty-one patients diagnosed with severe IGM were included in the study and treated with either local steroid injection (LSI) alone (n = 25) or combined LSI with systemic oral steroid treatment (OST) (n = 26). The local steroid injection protocol included an intralesional triamcinolone acetonide injection into the palpable granulomas every 4-week, and topical administration of steroid-containing pomades twice a day on the affected surface of the breast. Patients with a combined LSI and OST received low-dose oral methylprednisolone (<16 mg). RESULTS: Patients with LSI alone required more LSI applications than those in the combined LSI with OST group (LSI: 5 ± 2.9; vs. LSI/OST: 3.5 ± 2.5; p = 0.080) to obtain an effective optimum therapeutic response. At a median of 12 months (range, 4–42), no difference was found in complete response rates between patients in the LSI group and the combined LSI group with OST (52 vs. 53.9%, p = 0.999). However, steroid-related systemic side effects were lower in the LSI alone group (p < 0.008). CONCLUSION: Local steroid injection could be considered as the first-line treatment in patients with severe IGM until a therapeutic response has been obtained either as the sole treatment modality or combined with oral steroids. Compared with systemic oral steroid therapy, local steroid administration can be considered a new treatment modality with fewer side effects. Frontiers Media S.A. 2023-10-04 /pmc/articles/PMC10582626/ /pubmed/37859855 http://dx.doi.org/10.3389/fmed.2023.1251851 Text en Copyright © 2023 Cabioglu, Uras, Mutlu, Sezgin, Emiroglu, Dulgeroglu, Yılmaz, Tukenmez, Arikan, Kara and Muslumanoglu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Cabioglu, Neslihan Uras, Cihan Mutlu, Halime Sezgin, Derya Emiroglu, Selman Dulgeroglu, Onur Yilmaz, Ravza Tukenmez, Mustafa Arikan, Akif Enes Kara, Halil Muslumanoglu, Mahmut Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy |
title | Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy |
title_full | Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy |
title_fullStr | Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy |
title_full_unstemmed | Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy |
title_short | Local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy |
title_sort | local steroid injection in severe idiopathic granulomatous mastitis as a new first-line treatment modality with promising therapeutic efficacy |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582626/ https://www.ncbi.nlm.nih.gov/pubmed/37859855 http://dx.doi.org/10.3389/fmed.2023.1251851 |
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