GOLD-Induced Cytokine (GOLDIC): A Game-Changer Orthobiologic in Regenerative Medicine

Due to the Industry 4.0 and Industry 5.0 revolutions, researchers, clinicians, and regenerative medicine experts are exploring the plausibility of regenerating diseased or degenerated tissues to regain their near-normal biomechanical properties. In the past three decades, research on “Tissue Engineering and Regenerative Medicine” (TERM) has attained various milestones in clinical translation from bench to bedside. The regulatory bodies of various countries and states are working on the ethical use and guidelines for the production and storage of various cellular and acellular products. Platelets and platelet-derived by-products play a significant role in TERM. The growth factors and cytokines present in platelets regenerate the tissue of interest. In this connotation, a newer orthobiologic called “GOLD-induced cytokine” (GOLDIC) has become a product of interest among various regenerative medicine experts and researchers around the globe. Due to its potent anti-inflammatory action and potential systemic side effects, gold has been withdrawn from the management panel for rheumatoid arthritis. With the knowledge of its anti-inflammatory properties, researchers explored the utility of gold for tissue regeneration.