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An innovative phase I study in healthy subjects to determine the mass balance, elimination, metabolism, and absolute bioavailability of mitapivat

Mitapivat, a first‐in‐class, oral, small‐molecule, allosteric activator of the red blood cell‐specific form of pyruvate kinase (PKR), was approved for the treatment of hemolytic anemia in adults with pyruvate kinase (PK) deficiency. In this phase I mass balance study in healthy males, we administere...

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Detalles Bibliográficos
Autores principales:	Prakash, Chandra, Mangus, Heidi, Yan, Yan, Yang, Hua, Iyer, Varsha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582659/ https://www.ncbi.nlm.nih.gov/pubmed/37596712 http://dx.doi.org/10.1111/cts.13609

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