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Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study
We aimed to explore excessive daytime sleepiness (EDS) and correlates of clinical characteristics by using cross‐sectional and longitudinal analyses from the Parkinson's Progression Markers Initiative database. Four hundred twenty‐three patients with Parkinson's disease (PD; EDS: non‐EDS =...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582661/ https://www.ncbi.nlm.nih.gov/pubmed/37551840 http://dx.doi.org/10.1111/cts.13610 |
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author | Liu, Yumei Xue, Ling Zhao, Jun Dou, Kaixin Wang, Guojun Xie, Anmu |
author_facet | Liu, Yumei Xue, Ling Zhao, Jun Dou, Kaixin Wang, Guojun Xie, Anmu |
author_sort | Liu, Yumei |
collection | PubMed |
description | We aimed to explore excessive daytime sleepiness (EDS) and correlates of clinical characteristics by using cross‐sectional and longitudinal analyses from the Parkinson's Progression Markers Initiative database. Four hundred twenty‐three patients with Parkinson's disease (PD; EDS: non‐EDS = 357:66) and 195 healthy controls (HCs; EDS: nEDS = 171:24) were enrolled in our study at baseline. Multiple linear and linear mixed‐effects models were used to research the relationships between EDS/daytime sleepiness severity and clinical characteristics. Relationships between the change rates of clinical characteristics and daytime sleepiness severity were further investigated through multiple linear regression models. Mediating effect analysis was used to determine whether autonomic dysfunction was the mediator between cognition assessments and daytime sleepiness severity. Patients with PD with EDS and greater daytime sleepiness severity presented faster cognitive decline, high possibility for rapid eye movement sleep behavior disorder, autonomic dysfunction, depression, and anxiety from cross‐sectional and longitudinal analyses. Furthermore, HC individuals with EDS showed a higher striatal binding ratio of the right putamen, right striatum, and mean striatum. Autonomic dysfunction may act as a mediator between PD and cognitive decline. In early PD, EDS and daytime sleepiness severity were related to several clinical variables, suggesting that EDS might play an essential role in regulating PD progression. |
format | Online Article Text |
id | pubmed-10582661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105826612023-10-19 Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study Liu, Yumei Xue, Ling Zhao, Jun Dou, Kaixin Wang, Guojun Xie, Anmu Clin Transl Sci Research We aimed to explore excessive daytime sleepiness (EDS) and correlates of clinical characteristics by using cross‐sectional and longitudinal analyses from the Parkinson's Progression Markers Initiative database. Four hundred twenty‐three patients with Parkinson's disease (PD; EDS: non‐EDS = 357:66) and 195 healthy controls (HCs; EDS: nEDS = 171:24) were enrolled in our study at baseline. Multiple linear and linear mixed‐effects models were used to research the relationships between EDS/daytime sleepiness severity and clinical characteristics. Relationships between the change rates of clinical characteristics and daytime sleepiness severity were further investigated through multiple linear regression models. Mediating effect analysis was used to determine whether autonomic dysfunction was the mediator between cognition assessments and daytime sleepiness severity. Patients with PD with EDS and greater daytime sleepiness severity presented faster cognitive decline, high possibility for rapid eye movement sleep behavior disorder, autonomic dysfunction, depression, and anxiety from cross‐sectional and longitudinal analyses. Furthermore, HC individuals with EDS showed a higher striatal binding ratio of the right putamen, right striatum, and mean striatum. Autonomic dysfunction may act as a mediator between PD and cognitive decline. In early PD, EDS and daytime sleepiness severity were related to several clinical variables, suggesting that EDS might play an essential role in regulating PD progression. John Wiley and Sons Inc. 2023-08-17 /pmc/articles/PMC10582661/ /pubmed/37551840 http://dx.doi.org/10.1111/cts.13610 Text en © 2023 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Liu, Yumei Xue, Ling Zhao, Jun Dou, Kaixin Wang, Guojun Xie, Anmu Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study |
title | Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study |
title_full | Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study |
title_fullStr | Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study |
title_full_unstemmed | Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study |
title_short | Clinical characteristics in early Parkinson's disease with excessive daytime sleepiness: A cross‐sectional and longitudinal study |
title_sort | clinical characteristics in early parkinson's disease with excessive daytime sleepiness: a cross‐sectional and longitudinal study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582661/ https://www.ncbi.nlm.nih.gov/pubmed/37551840 http://dx.doi.org/10.1111/cts.13610 |
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