Intradermal substance P as a challenge agent in healthy individuals

Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a potential challenge agent for investigating local mediators, is associated with wheal and flare response mediated by the MRGPRX2 receptor. Alt...

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Detalles Bibliográficos
Autores principales: ten Voorde, Wouter, Akinseye, Chika, Abdisalaam, Ismahaan, Wind, Selinde, Klarenbeek, Naomi, Bergmans, Menthe, van Doorn, Martijn, Rissmann, Robert, Kaur, Rejbinder, Hotee, Sarah, Foster, Katie, Nair, Arati, Fortunato, Lea, Macphee, Colin, Mole, Sarah, Baumann, Katrine, Brigandi, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582677/
https://www.ncbi.nlm.nih.gov/pubmed/37547990
http://dx.doi.org/10.1111/cts.13592

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