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A randomized, controlled single, and multiple ascending dose trial of the safety, pharmacokinetics and pharmacodynamics of SN1011 in healthy subjects

The purpose of this study was to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of SN1011, a novel Bruton tyrosine kinase (BTK) inhibitor, and food effects in healthy subjects. In this phase I trial, subjects received single ascending doses (SADs) of SN1011 (100 to 800 ...

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Detalles Bibliográficos
Autores principales:	Zhu, Leilei, Shi, Rong, Zhao, Tongfang, Ye, Yujie, Tang, Jie, Hu, Yihui, Peng, Peng, Wang, Dong, Chong, Clement, Xu, Guolin, Leung, Shui‐on, Yuan, Wei’an
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582678/ https://www.ncbi.nlm.nih.gov/pubmed/37551782 http://dx.doi.org/10.1111/cts.13606

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