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Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity
Cancer cell heterogeneity is a key contributor to therapeutic failure and post-treatment recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence seems to be an attractive approach to improve treatment outcome in cancer patients. However, this remains challenging due...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582728/ https://www.ncbi.nlm.nih.gov/pubmed/37860822 http://dx.doi.org/10.3389/fcell.2023.1231416 |
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author | Brisset, Morgan Mehlen, Patrick Meurette, Olivier Hollande, Frédéric |
author_facet | Brisset, Morgan Mehlen, Patrick Meurette, Olivier Hollande, Frédéric |
author_sort | Brisset, Morgan |
collection | PubMed |
description | Cancer cell heterogeneity is a key contributor to therapeutic failure and post-treatment recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence seems to be an attractive approach to improve treatment outcome in cancer patients. However, this remains challenging due to the complexity and incomplete characterization of tumor cell subpopulations. The heterogeneity of cells exhibiting stemness-related features, such as self-renewal and chemoresistance, fuels this complexity. Notch signaling is a known regulator of cancer stem cell (CSC) features in colorectal cancer (CRC), though the effects of its heterogenous signaling on CRC cell stemness are only just emerging. In this review, we discuss how Notch ligand-receptor specificity contributes to regulating stemness, self-renewal, chemoresistance and cancer stem cells heterogeneity in CRC. |
format | Online Article Text |
id | pubmed-10582728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105827282023-10-19 Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity Brisset, Morgan Mehlen, Patrick Meurette, Olivier Hollande, Frédéric Front Cell Dev Biol Cell and Developmental Biology Cancer cell heterogeneity is a key contributor to therapeutic failure and post-treatment recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence seems to be an attractive approach to improve treatment outcome in cancer patients. However, this remains challenging due to the complexity and incomplete characterization of tumor cell subpopulations. The heterogeneity of cells exhibiting stemness-related features, such as self-renewal and chemoresistance, fuels this complexity. Notch signaling is a known regulator of cancer stem cell (CSC) features in colorectal cancer (CRC), though the effects of its heterogenous signaling on CRC cell stemness are only just emerging. In this review, we discuss how Notch ligand-receptor specificity contributes to regulating stemness, self-renewal, chemoresistance and cancer stem cells heterogeneity in CRC. Frontiers Media S.A. 2023-10-04 /pmc/articles/PMC10582728/ /pubmed/37860822 http://dx.doi.org/10.3389/fcell.2023.1231416 Text en Copyright © 2023 Brisset, Mehlen, Meurette and Hollande. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Brisset, Morgan Mehlen, Patrick Meurette, Olivier Hollande, Frédéric Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity |
title | Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity |
title_full | Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity |
title_fullStr | Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity |
title_full_unstemmed | Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity |
title_short | Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity |
title_sort | notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582728/ https://www.ncbi.nlm.nih.gov/pubmed/37860822 http://dx.doi.org/10.3389/fcell.2023.1231416 |
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