Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds

Neurodegenerative tauopathies are caused by the transition of tau protein from a monomer to a toxic aggregate. They include Alzheimer disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick disease (PiD). We have previously proposed that tau monomer exists in tw...

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Detalles Bibliográficos
Autores principales: Hitt, Brian D., Gupta, Ankit, Singh, Ruhar, Yang, Ting, Beaver, Joshua D., Shang, Ping, White, Charles L., Joachimiak, Lukasz A., Diamond, Marc I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582770/
https://www.ncbi.nlm.nih.gov/pubmed/37714465
http://dx.doi.org/10.1016/j.jbc.2023.105252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582770/
https://www.ncbi.nlm.nih.gov/pubmed/37714465
http://dx.doi.org/10.1016/j.jbc.2023.105252

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