C-reactive protein impairs immune response of CD8(+) T cells via FcγRIIb-p38MAPK-ROS axis in multiple myeloma

BACKGROUND: C-reactive protein (CRP) is a prototypical acute phase protein in humans with the function of regulating immune cells. Serum CRP levels are elevated in multiple myeloma (MM), associated with MM cell proliferation and bone destruction. However, its direct effects on T lymphocytes in MM ha...

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Detalles Bibliográficos
Autores principales: Jiang, Jinxing, Peng, Ziyi, Wang, Junying, Chen, Mengping, Wan, Yike, Huang, Honghui, Liu, Zhiqiang, Wang, Jingya, Hou, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582887/
https://www.ncbi.nlm.nih.gov/pubmed/37844994
http://dx.doi.org/10.1136/jitc-2023-007593

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