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Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis
BACKGROUND: We aim to assess the impact of montelukast on paediatric patients with asthma/allergic rhinitis, measured using patient-reported outcome measures, compared with other treatments or placebo. METHODS: Protocol registration CRD42020216098 (www.crd.york.ac.uk/PROSPERO). MEDLINE and Embase da...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582929/ https://www.ncbi.nlm.nih.gov/pubmed/37852659 http://dx.doi.org/10.1183/16000617.0124-2023 |
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author | Mayoral, Karina Lizano-Barrantes, Catalina Zamora, Víctor Pont, Angels Miret, Carme Barrufet, Cristina Caballero-Rabasco, M. Araceli Praena-Crespo, Manuel Bercedo, Alberto Valdesoiro-Navarrete, Laura Guerra, Maria Teresa Pardo, Yolanda Martínez Zapata, Mª José Garin, Olatz Ferrer, Montse |
author_facet | Mayoral, Karina Lizano-Barrantes, Catalina Zamora, Víctor Pont, Angels Miret, Carme Barrufet, Cristina Caballero-Rabasco, M. Araceli Praena-Crespo, Manuel Bercedo, Alberto Valdesoiro-Navarrete, Laura Guerra, Maria Teresa Pardo, Yolanda Martínez Zapata, Mª José Garin, Olatz Ferrer, Montse |
author_sort | Mayoral, Karina |
collection | PubMed |
description | BACKGROUND: We aim to assess the impact of montelukast on paediatric patients with asthma/allergic rhinitis, measured using patient-reported outcome measures, compared with other treatments or placebo. METHODS: Protocol registration CRD42020216098 (www.crd.york.ac.uk/PROSPERO). MEDLINE and Embase databases were used to conduct the search. Two authors independently selected studies and extracted data, and a third reviewer resolved discrepancies. Meta-analyses were constructed to estimate the standardised mean difference (SMD) using a random-effects model. RESULTS: Out of 3937 articles identified, 49 studies met the inclusion criteria, mostly randomised clinical trials (sample sizes: 21–689 patients). The SMD of change pooled estimators for the global, mental and physical domains of health-related quality of life were not statistically significant. For daytime and night-time symptoms scores, the SMD (95% CI) was in favour of inhaled corticosteroids (−0.12, −0.20– −0.05 and −0.23, −0.41– −0.06, respectively). The pooled estimator for global asthma symptoms was better for montelukast when compared with placebo (0.90, 0.44–1.36). CONCLUSIONS: The synthesis of the available evidence suggests that, in children and adolescents, montelukast was effective in controlling asthma symptoms when compared with placebo, but inhaled corticosteroids were superior in controlling symptoms, especially at night-time. These findings of our systematic review concur with current guidelines for asthma treatment. |
format | Online Article Text |
id | pubmed-10582929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-105829292023-10-19 Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis Mayoral, Karina Lizano-Barrantes, Catalina Zamora, Víctor Pont, Angels Miret, Carme Barrufet, Cristina Caballero-Rabasco, M. Araceli Praena-Crespo, Manuel Bercedo, Alberto Valdesoiro-Navarrete, Laura Guerra, Maria Teresa Pardo, Yolanda Martínez Zapata, Mª José Garin, Olatz Ferrer, Montse Eur Respir Rev Reviews BACKGROUND: We aim to assess the impact of montelukast on paediatric patients with asthma/allergic rhinitis, measured using patient-reported outcome measures, compared with other treatments or placebo. METHODS: Protocol registration CRD42020216098 (www.crd.york.ac.uk/PROSPERO). MEDLINE and Embase databases were used to conduct the search. Two authors independently selected studies and extracted data, and a third reviewer resolved discrepancies. Meta-analyses were constructed to estimate the standardised mean difference (SMD) using a random-effects model. RESULTS: Out of 3937 articles identified, 49 studies met the inclusion criteria, mostly randomised clinical trials (sample sizes: 21–689 patients). The SMD of change pooled estimators for the global, mental and physical domains of health-related quality of life were not statistically significant. For daytime and night-time symptoms scores, the SMD (95% CI) was in favour of inhaled corticosteroids (−0.12, −0.20– −0.05 and −0.23, −0.41– −0.06, respectively). The pooled estimator for global asthma symptoms was better for montelukast when compared with placebo (0.90, 0.44–1.36). CONCLUSIONS: The synthesis of the available evidence suggests that, in children and adolescents, montelukast was effective in controlling asthma symptoms when compared with placebo, but inhaled corticosteroids were superior in controlling symptoms, especially at night-time. These findings of our systematic review concur with current guidelines for asthma treatment. European Respiratory Society 2023-10-18 /pmc/articles/PMC10582929/ /pubmed/37852659 http://dx.doi.org/10.1183/16000617.0124-2023 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Reviews Mayoral, Karina Lizano-Barrantes, Catalina Zamora, Víctor Pont, Angels Miret, Carme Barrufet, Cristina Caballero-Rabasco, M. Araceli Praena-Crespo, Manuel Bercedo, Alberto Valdesoiro-Navarrete, Laura Guerra, Maria Teresa Pardo, Yolanda Martínez Zapata, Mª José Garin, Olatz Ferrer, Montse Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis |
title | Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis |
title_full | Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis |
title_fullStr | Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis |
title_full_unstemmed | Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis |
title_short | Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis |
title_sort | montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582929/ https://www.ncbi.nlm.nih.gov/pubmed/37852659 http://dx.doi.org/10.1183/16000617.0124-2023 |
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