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Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis
Joint replacement surgery is the most effective treatment for end-stage arthritis. Aseptic loosening caused by periprosthetic osteolysis is a common complication after joint replacement. Inflammation induced by wear particles derived from prosthetic biomaterials is a major cause of osteolysis. We em...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582964/ https://www.ncbi.nlm.nih.gov/pubmed/37860014 http://dx.doi.org/10.3389/fimmu.2023.1274679 |
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author | Yin, Zhaoyang Gong, Ge Liu, Xinhui Yin, Jian |
author_facet | Yin, Zhaoyang Gong, Ge Liu, Xinhui Yin, Jian |
author_sort | Yin, Zhaoyang |
collection | PubMed |
description | Joint replacement surgery is the most effective treatment for end-stage arthritis. Aseptic loosening caused by periprosthetic osteolysis is a common complication after joint replacement. Inflammation induced by wear particles derived from prosthetic biomaterials is a major cause of osteolysis. We emphasize that bone marrow-derived macrophages and their fusion-derived osteoclasts play a key role in this pathological process. Researchers have developed multiple intervention approaches to regulate macrophage/osteoclast activation. Aiming at wear particle-induced periprosthetic aseptic osteolysis, this review separately discusses the molecular mechanism of regulation of ROS formation and inflammatory response through intervention of macrophage/osteoclast RANKL-MAPKs-NF-κB pathway. These molecular mechanisms regulate osteoclast activation in different ways, but they are not isolated from each other. There is also a lot of crosstalk among the different mechanisms. In addition, other bone and joint diseases related to osteoclast activation are also briefly introduced. Therefore, we discuss these new findings in the context of existing work with a view to developing new strategies for wear particle-associated osteolysis based on the regulation of macrophages/osteoclasts. |
format | Online Article Text |
id | pubmed-10582964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105829642023-10-19 Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis Yin, Zhaoyang Gong, Ge Liu, Xinhui Yin, Jian Front Immunol Immunology Joint replacement surgery is the most effective treatment for end-stage arthritis. Aseptic loosening caused by periprosthetic osteolysis is a common complication after joint replacement. Inflammation induced by wear particles derived from prosthetic biomaterials is a major cause of osteolysis. We emphasize that bone marrow-derived macrophages and their fusion-derived osteoclasts play a key role in this pathological process. Researchers have developed multiple intervention approaches to regulate macrophage/osteoclast activation. Aiming at wear particle-induced periprosthetic aseptic osteolysis, this review separately discusses the molecular mechanism of regulation of ROS formation and inflammatory response through intervention of macrophage/osteoclast RANKL-MAPKs-NF-κB pathway. These molecular mechanisms regulate osteoclast activation in different ways, but they are not isolated from each other. There is also a lot of crosstalk among the different mechanisms. In addition, other bone and joint diseases related to osteoclast activation are also briefly introduced. Therefore, we discuss these new findings in the context of existing work with a view to developing new strategies for wear particle-associated osteolysis based on the regulation of macrophages/osteoclasts. Frontiers Media S.A. 2023-10-04 /pmc/articles/PMC10582964/ /pubmed/37860014 http://dx.doi.org/10.3389/fimmu.2023.1274679 Text en Copyright © 2023 Yin, Gong, Liu and Yin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Yin, Zhaoyang Gong, Ge Liu, Xinhui Yin, Jian Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis |
title | Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis |
title_full | Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis |
title_fullStr | Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis |
title_full_unstemmed | Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis |
title_short | Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis |
title_sort | mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582964/ https://www.ncbi.nlm.nih.gov/pubmed/37860014 http://dx.doi.org/10.3389/fimmu.2023.1274679 |
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