Cargando…

Dihydroorotate dehydrogenase promotes cell proliferation and suppresses cell death in esophageal squamous cell carcinoma and colorectal carcinoma

BACKGROUND: Ferroptosis is defined as an iron-dependent non-apoptotic form of programmed cell death. Dihydroorotate dehydrogenase (DHODH) is a newly discovered anti-ferroptosis molecule independent from the well-known GPX4 and AIFM2. However, the expression pattern and especially the functional role...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Zhi-Zhou, Jin, Xin, Li, Wen-Ting, Tao, Hao, Song, Sheng-Jie, Fan, Ze-Wen, Jiang, Wen, Liang, Jian-Wei, Bai, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583008/ https://www.ncbi.nlm.nih.gov/pubmed/37859742 http://dx.doi.org/10.21037/tcr-23-136

Ejemplares similares

SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation
por: Qiu, Xuemei, et al.
Publicado: (2021)

Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay
por: Schölermann, Beate, et al.
Publicado: (2022)

Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells
por: Mei, Li-Li, et al.
Publicado: (2017)

Knockdown of lncRNAXLOC_001659 inhibits proliferation and invasion of esophageal squamous cell carcinoma cells
por: Li, Feng-Zhi, et al.
Publicado: (2019)

Bombyx mori Dihydroorotate Dehydrogenase: Knockdown Inhibits Cell Growth and Proliferation via Inducing Cell Cycle Arrest
por: Zhao, Erhu, et al.
Publicado: (2018)

An integrative framework to identify cell death-related microRNAs in esophageal squamous cell carcinoma
por: Wu, Bing-Li, et al.
Publicado: (2016)

Esophageal mycobiome landscape and interkingdom interactions in esophageal squamous cell carcinoma
por: Rao, Wen-Qing, et al.
Publicado: (2023)

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition
por: Arnould, Stéphanie, et al.
Publicado: (2017)

Apoptotic effect of gambogic acid in esophageal squamous cell carcinoma cells via suppression of the NF-κB pathway
por: LIU, WEN-YUE, et al.
Publicado: (2016)

Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment
por: Zheng, Yingxia, et al.
Publicado: (2020)

Silence of HDAC6 suppressed esophageal squamous cell carcinoma proliferation and migration by disrupting chaperone function of HSP90
por: Tao, Hua, et al.
Publicado: (2018)

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
por: Wu, Dang, et al.
Publicado: (2018)

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
por: KAWATANI, MAKOTO, et al.
Publicado: (2023)

Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway
por: Wu, Xiangyu, et al.
Publicado: (2021)

Genomic and molecular characterization of esophageal squamous cell carcinoma
por: Lin, De-Chen, et al.
Publicado: (2014)

Prognostic and diagnostic potential of isocitrate dehydrogenase 1 in esophageal squamous cell carcinoma
por: Chen, Xuan, et al.
Publicado: (2016)

Esophageal luminal stenosis is an independent prognostic factor in esophageal squamous cell carcinoma
por: Yang, Yu-Shang, et al.
Publicado: (2017)

Untargeted Metabolomics Analysis of Esophageal Squamous Cell Carcinoma Discovers Dysregulated Metabolic Pathways and Potential Diagnostic Biomarkers
por: Zhu, Zi-Jia, et al.
Publicado: (2020)

Up-regulation of SOCS4 promotes cell proliferation and migration in esophageal squamous cell carcinoma
por: Ying, Jie, et al.
Publicado: (2021)

Knockdown of RAD51AP1 suppressed cell proliferation and invasion in esophageal squamous cell carcinoma
por: Hu, Yang-Yang, et al.
Publicado: (2022)

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
por: Ross, Leila Saxby, et al.
Publicado: (2018)

Mysteries of partial dihydroorotate dehydrogenase inhibition and leukemia terminal differentiation
por: Saunthararajah, Yogen
Publicado: (2020)

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase
por: Xu, Yechun, et al.
Publicado: (2020)

A Novel Graph Neural Network Methodology to Investigate Dihydroorotate Dehydrogenase Inhibitors in Small Cell Lung Cancer
por: Zhi, Hong-Yi, et al.
Publicado: (2021)

Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase
por: Dorasamy, Mathura Subangari, et al.
Publicado: (2017)

Genomic characterization of a newly established esophageal squamous cell carcinoma cell line from China and published esophageal squamous cell carcinoma cell lines
por: Li, Xiang, et al.
Publicado: (2020)

Signatures within esophageal microbiota with progression of esophageal squamous cell carcinoma
por: Li, Minjuan, et al.
Publicado: (2020)

Assessment of Early Growth Response 1 in Tumor Suppression of Esophageal Squamous Cell Carcinoma
por: Tseng, Yen-Chiang, et al.
Publicado: (2022)

Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells
por: Eriksen‐Gjerstad, May, et al.
Publicado: (2022)

miR-145-5p Suppresses Tumor Cell Migration, Invasion and Epithelial to Mesenchymal Transition by Regulating the Sp1/NF-κB Signaling Pathway in Esophageal Squamous Cell Carcinoma
por: Mei, Li-Li, et al.
Publicado: (2017)

Pharmaceutical inhibition of AXL suppresses tumor growth and invasion of esophageal squamous cell carcinoma
por: Han, Sha, et al.
Publicado: (2020)

Simvastatin, but not pravastatin, inhibits the proliferation of esophageal adenocarcinoma and squamous cell carcinoma cells: a cell-molecular study
por: Chen, Yan, et al.
Publicado: (2018)

Parthenolide Inhibits Angiogenesis in Esophageal Squamous Cell Carcinoma Through Suppression of VEGF
por: Tian, Bo, et al.
Publicado: (2020)

Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma
por: Cheng, Rui, et al.
Publicado: (2018)

Fluorescence assay of dihydroorotate dehydrogenase that may become a cancer biomarker
por: Yin, Sheng, et al.
Publicado: (2017)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2018)

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines
por: Horwitz, Samantha M., et al.
Publicado: (2022)

Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
por: Houshmand, Mohammad, et al.
Publicado: (2022)

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions
por: Miyazaki, Yukiko, et al.
Publicado: (2018)

Cloperastine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by suppressing mitochondrial oxidative phosphorylation
por: Li, Bo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lfepkiist5o0gpm0dqgg0ml7db