A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population

The role of alternative polyadenylation (APA) in tumor development is becoming increasingly evident, but the impact of APA events on the prognosis of LUAD patients is unclear. Therefore, in the present study, we aimed to analyze specific APA events in LUAD to identify novel prognostic biomarkers for...

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Autores principales: Zhang, Wendi, Hu, Yang, Qian, Min, Mao, Liping, Yuan, Yanqiong, Xu, Huiwen, Liu, Yiran, Qiu, Anni, Zhou, Yan, Dong, Yang, Wu, Yutong, Chen, Qiong, Tao, Xiaobo, Tian, Tian, Zhang, Lei, Cui, Jiahua, Chu, Minjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583048/
https://www.ncbi.nlm.nih.gov/pubmed/37860689
http://dx.doi.org/10.1016/j.isci.2023.108068
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author Zhang, Wendi
Hu, Yang
Qian, Min
Mao, Liping
Yuan, Yanqiong
Xu, Huiwen
Liu, Yiran
Qiu, Anni
Zhou, Yan
Dong, Yang
Wu, Yutong
Chen, Qiong
Tao, Xiaobo
Tian, Tian
Zhang, Lei
Cui, Jiahua
Chu, Minjie
author_facet Zhang, Wendi
Hu, Yang
Qian, Min
Mao, Liping
Yuan, Yanqiong
Xu, Huiwen
Liu, Yiran
Qiu, Anni
Zhou, Yan
Dong, Yang
Wu, Yutong
Chen, Qiong
Tao, Xiaobo
Tian, Tian
Zhang, Lei
Cui, Jiahua
Chu, Minjie
author_sort Zhang, Wendi
collection PubMed
description The role of alternative polyadenylation (APA) in tumor development is becoming increasingly evident, but the impact of APA events on the prognosis of LUAD patients is unclear. Therefore, in the present study, we aimed to analyze specific APA events in LUAD to identify novel prognostic biomarkers for LUAD. We first identified prognostic candidate genes for LUAD associated with APA events and validated them in both the East Asian and the USA cohorts, finding that five genes (DCUN1D5, PSMC4, TFAM, THRA, and TMEM100) were of prognostic significance in both populations. Based on this, an APA-based prognostic signature was constructed for the East Asian population. The predictive accuracy of the prognostic signature was further evaluated by the time-dependent ROC, with 1-, 2-, and 3-year AUCs of 0.86, 0.81, and 0.71, respectively. This study may provide new markers for individualized diagnosis and prognostic assessment of LUAD and potential targets for precision treatment.
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spelling pubmed-105830482023-10-19 A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population Zhang, Wendi Hu, Yang Qian, Min Mao, Liping Yuan, Yanqiong Xu, Huiwen Liu, Yiran Qiu, Anni Zhou, Yan Dong, Yang Wu, Yutong Chen, Qiong Tao, Xiaobo Tian, Tian Zhang, Lei Cui, Jiahua Chu, Minjie iScience Article The role of alternative polyadenylation (APA) in tumor development is becoming increasingly evident, but the impact of APA events on the prognosis of LUAD patients is unclear. Therefore, in the present study, we aimed to analyze specific APA events in LUAD to identify novel prognostic biomarkers for LUAD. We first identified prognostic candidate genes for LUAD associated with APA events and validated them in both the East Asian and the USA cohorts, finding that five genes (DCUN1D5, PSMC4, TFAM, THRA, and TMEM100) were of prognostic significance in both populations. Based on this, an APA-based prognostic signature was constructed for the East Asian population. The predictive accuracy of the prognostic signature was further evaluated by the time-dependent ROC, with 1-, 2-, and 3-year AUCs of 0.86, 0.81, and 0.71, respectively. This study may provide new markers for individualized diagnosis and prognostic assessment of LUAD and potential targets for precision treatment. Elsevier 2023-09-28 /pmc/articles/PMC10583048/ /pubmed/37860689 http://dx.doi.org/10.1016/j.isci.2023.108068 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Wendi
Hu, Yang
Qian, Min
Mao, Liping
Yuan, Yanqiong
Xu, Huiwen
Liu, Yiran
Qiu, Anni
Zhou, Yan
Dong, Yang
Wu, Yutong
Chen, Qiong
Tao, Xiaobo
Tian, Tian
Zhang, Lei
Cui, Jiahua
Chu, Minjie
A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
title A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
title_full A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
title_fullStr A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
title_full_unstemmed A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
title_short A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population
title_sort novel apa-based prognostic signature may predict the prognosis of lung adenocarcinoma in an east asian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583048/
https://www.ncbi.nlm.nih.gov/pubmed/37860689
http://dx.doi.org/10.1016/j.isci.2023.108068
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