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Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study

BACKGROUND AND OBJECTIVES: While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear. Thus, the aim of this study was to explore this association in...

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Autores principales: Daka, Bledar, Bennet, Louise, Råstam, Lennart, Hellgren, Margareta I, Li, Ying, Magnusson, Martin, Lindblad, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583109/
https://www.ncbi.nlm.nih.gov/pubmed/37821143
http://dx.doi.org/10.1136/bmjopen-2022-069937
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author Daka, Bledar
Bennet, Louise
Råstam, Lennart
Hellgren, Margareta I
Li, Ying
Magnusson, Martin
Lindblad, Ulf
author_facet Daka, Bledar
Bennet, Louise
Råstam, Lennart
Hellgren, Margareta I
Li, Ying
Magnusson, Martin
Lindblad, Ulf
author_sort Daka, Bledar
collection PubMed
description BACKGROUND AND OBJECTIVES: While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear. Thus, the aim of this study was to explore this association in a representative population sample employing optimal echocardiographic techniques. DESIGN: Cross-sectional observational study in community-based population. SETTINGS, PARTICIPANTS AND METHODS: Participants between 30 and 75 years of age were consecutively invited to a physical examination, interview, conventional echocardiography, including Tissue Velocity Imaging. Diastolic dysfunction was defined according to the European Society of Cardiology criteria, excluding subjects with ejection fraction <45%, self-reported history of heart failure or atrial fibrillation on ECG. Self-reported alcohol intake using a validated questionnaire was categorised as no intake, low and medium-high intake. RESULTS: In total, 500 men and 538 women (mean age 55.4±13) were successfully examined. Diastolic dysfunction was identified in 16% (79/500) of the men and 13% (58/538) of the women. The multivariable adjusted model revealed a strong and independent association between alcohol intake and diastolic dysfunction. In fact, using no alcohol intake as reference, diastolic dysfunction was independently associated with alcohol consumption in a dose-dependent fashion; low consumption, OR 2.3 (95% CI 1.3 to 4.0) and medium-high consumption OR 3.1 (95% CI 1.6 to 6.2), respectively. CONCLUSION: There was a significant association between alcohol consumption and diastolic dysfunction starting already at low levels that was supported by a dose-dependent pattern. These results need confirmatory studies and are important in public health policies.
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spelling pubmed-105831092023-10-19 Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study Daka, Bledar Bennet, Louise Råstam, Lennart Hellgren, Margareta I Li, Ying Magnusson, Martin Lindblad, Ulf BMJ Open Cardiovascular Medicine BACKGROUND AND OBJECTIVES: While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear. Thus, the aim of this study was to explore this association in a representative population sample employing optimal echocardiographic techniques. DESIGN: Cross-sectional observational study in community-based population. SETTINGS, PARTICIPANTS AND METHODS: Participants between 30 and 75 years of age were consecutively invited to a physical examination, interview, conventional echocardiography, including Tissue Velocity Imaging. Diastolic dysfunction was defined according to the European Society of Cardiology criteria, excluding subjects with ejection fraction <45%, self-reported history of heart failure or atrial fibrillation on ECG. Self-reported alcohol intake using a validated questionnaire was categorised as no intake, low and medium-high intake. RESULTS: In total, 500 men and 538 women (mean age 55.4±13) were successfully examined. Diastolic dysfunction was identified in 16% (79/500) of the men and 13% (58/538) of the women. The multivariable adjusted model revealed a strong and independent association between alcohol intake and diastolic dysfunction. In fact, using no alcohol intake as reference, diastolic dysfunction was independently associated with alcohol consumption in a dose-dependent fashion; low consumption, OR 2.3 (95% CI 1.3 to 4.0) and medium-high consumption OR 3.1 (95% CI 1.6 to 6.2), respectively. CONCLUSION: There was a significant association between alcohol consumption and diastolic dysfunction starting already at low levels that was supported by a dose-dependent pattern. These results need confirmatory studies and are important in public health policies. BMJ Publishing Group 2023-10-11 /pmc/articles/PMC10583109/ /pubmed/37821143 http://dx.doi.org/10.1136/bmjopen-2022-069937 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Cardiovascular Medicine
Daka, Bledar
Bennet, Louise
Råstam, Lennart
Hellgren, Margareta I
Li, Ying
Magnusson, Martin
Lindblad, Ulf
Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
title Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
title_full Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
title_fullStr Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
title_full_unstemmed Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
title_short Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
title_sort association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583109/
https://www.ncbi.nlm.nih.gov/pubmed/37821143
http://dx.doi.org/10.1136/bmjopen-2022-069937
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