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A comprehensive evaluation in clinic and physiologically‐based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450–mediated drug–drug interaction potential for pomotrelvir

Pomotrelvir is a new chemical entity and potent direct‐acting antiviral inhibitor of the main protease of coronaviruses. Here the cytochrome P450 (CYP)–mediated drug–drug interaction (DDI) potential of pomotrelvir was evaluated for major CYP isoforms, starting with in vitro assays followed by the ba...

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Detalles Bibliográficos
Autores principales:	Yang, Ziping, Rioux, Nathalie, Vincent, Ludwig, Jones, Hannah M., Cha, David, Plummer, Andrew, Wilfret, David, Kearney, Brian P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583239/ https://www.ncbi.nlm.nih.gov/pubmed/37614073 http://dx.doi.org/10.1002/psp4.13034

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