A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity

We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic‐induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in the small intestinal epithelium and integrates heterogeneous epithelial‐related...

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Detalles Bibliográficos
Autores principales: Gall, Louis, Jardi, Ferran, Lammens, Lieve, Piñero, Janet, Souza, Terezinha M., Rodrigues, Daniela, Jennen, Danyel G. J., de Kok, Theo M., Coyle, Luke, Chung, Seung‐Wook, Ferreira, Sofia, Jo, Heeseung, Beattie, Kylie A., Kelly, Colette, Duckworth, Carrie A., Pritchard, D. Mark, Pin, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583244/
https://www.ncbi.nlm.nih.gov/pubmed/37621010
http://dx.doi.org/10.1002/psp4.13029

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