Localising individual atoms of tryptophan side chains in the metallo-β-lactamase IMP-1 by pseudocontact shifts from paramagnetic lanthanoid tags at multiple sites

The metallo- [Formula: see text] -lactamase IMP-1 features a flexible loop near the active site that assumes different conformations in single crystal structures, which may assist in substrate binding and enzymatic activity. To probe the position of this loop, we labelled the tryptophan residues of...

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Detalles Bibliográficos
Autores principales: Orton, Henry W., Herath, Iresha D., Maleckis, Ansis, Jabar, Shereen, Szabo, Monika, Graham, Bim, Breen, Colum, Topping, Lydia, Butler, Stephen J., Otting, Gottfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583275/
https://www.ncbi.nlm.nih.gov/pubmed/37905175
http://dx.doi.org/10.5194/mr-3-1-2022

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