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Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study

BACKGROUND: Amygdala, an essential element of the limbic system, has served as an important structure in pain modulation. There is still a lack of clarity about altered cerebral perfusion of amygdala in migraine. This study aimed to investigate the perfusion variances of bilateral amygdala in episod...

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Autores principales: Bai, Xiaoyan, Wang, Wei, Zhang, Xueyan, Hu, Zhangxuan, Zhang, Xue, Zhang, Yingkui, Tang, Hefei, Zhang, Yaqing, Yu, Xueying, Yuan, Ziyu, Zhang, Peng, Li, Zhiye, Pei, Xun, Wang, Yonggang, Sui, Binbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583377/
https://www.ncbi.nlm.nih.gov/pubmed/37848831
http://dx.doi.org/10.1186/s10194-023-01668-0
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author Bai, Xiaoyan
Wang, Wei
Zhang, Xueyan
Hu, Zhangxuan
Zhang, Xue
Zhang, Yingkui
Tang, Hefei
Zhang, Yaqing
Yu, Xueying
Yuan, Ziyu
Zhang, Peng
Li, Zhiye
Pei, Xun
Wang, Yonggang
Sui, Binbin
author_facet Bai, Xiaoyan
Wang, Wei
Zhang, Xueyan
Hu, Zhangxuan
Zhang, Xue
Zhang, Yingkui
Tang, Hefei
Zhang, Yaqing
Yu, Xueying
Yuan, Ziyu
Zhang, Peng
Li, Zhiye
Pei, Xun
Wang, Yonggang
Sui, Binbin
author_sort Bai, Xiaoyan
collection PubMed
description BACKGROUND: Amygdala, an essential element of the limbic system, has served as an important structure in pain modulation. There is still a lack of clarity about altered cerebral perfusion of amygdala in migraine. This study aimed to investigate the perfusion variances of bilateral amygdala in episodic migraine (EM) and chronic migraine (CM) using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI). METHODS: Twenty-six patients with EM, 55 patients with CM (33 CM with medication overuse headache (MOH)), and 26 age- and sex-matched healthy controls (HCs) were included. All participants underwent 3D multi-delay pCASL MR imaging to obtain cerebral perfusion data, including arrival-time-corrected cerebral blood flow (CBF) and arterial cerebral blood volume (aCBV). The CBF and aCBV values in the bilateral amygdala were compared among the three groups. Correlation analyses between cerebral perfusion parameters and clinical variables were performed. RESULTS: Compared with HC participants, patients with CM were found to have increased CBF and aCBV values in the left amygdala, as well as increased CBF values in the right amygdala (all P < 0.05). There were no significant differences of CBF and aCBV values in the bilateral amygdala between the HC and EM groups, the EM and CM groups, as well as the CM without and with MOH groups (all P > 0.05). In patients with CM, the increased perfusion parameters of bilateral amygdala were positively correlated with MIDAS score after adjustments for age, sex, and body mass index (BMI). CONCLUSION: Hyperperfusion of bilateral amygdala might provide potential hemodynamics evidence in the neurolimbic pain network of CM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s10194-023-01668-0.
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spelling pubmed-105833772023-10-19 Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study Bai, Xiaoyan Wang, Wei Zhang, Xueyan Hu, Zhangxuan Zhang, Xue Zhang, Yingkui Tang, Hefei Zhang, Yaqing Yu, Xueying Yuan, Ziyu Zhang, Peng Li, Zhiye Pei, Xun Wang, Yonggang Sui, Binbin J Headache Pain Research BACKGROUND: Amygdala, an essential element of the limbic system, has served as an important structure in pain modulation. There is still a lack of clarity about altered cerebral perfusion of amygdala in migraine. This study aimed to investigate the perfusion variances of bilateral amygdala in episodic migraine (EM) and chronic migraine (CM) using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI). METHODS: Twenty-six patients with EM, 55 patients with CM (33 CM with medication overuse headache (MOH)), and 26 age- and sex-matched healthy controls (HCs) were included. All participants underwent 3D multi-delay pCASL MR imaging to obtain cerebral perfusion data, including arrival-time-corrected cerebral blood flow (CBF) and arterial cerebral blood volume (aCBV). The CBF and aCBV values in the bilateral amygdala were compared among the three groups. Correlation analyses between cerebral perfusion parameters and clinical variables were performed. RESULTS: Compared with HC participants, patients with CM were found to have increased CBF and aCBV values in the left amygdala, as well as increased CBF values in the right amygdala (all P < 0.05). There were no significant differences of CBF and aCBV values in the bilateral amygdala between the HC and EM groups, the EM and CM groups, as well as the CM without and with MOH groups (all P > 0.05). In patients with CM, the increased perfusion parameters of bilateral amygdala were positively correlated with MIDAS score after adjustments for age, sex, and body mass index (BMI). CONCLUSION: Hyperperfusion of bilateral amygdala might provide potential hemodynamics evidence in the neurolimbic pain network of CM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s10194-023-01668-0. Springer Milan 2023-10-18 /pmc/articles/PMC10583377/ /pubmed/37848831 http://dx.doi.org/10.1186/s10194-023-01668-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bai, Xiaoyan
Wang, Wei
Zhang, Xueyan
Hu, Zhangxuan
Zhang, Xue
Zhang, Yingkui
Tang, Hefei
Zhang, Yaqing
Yu, Xueying
Yuan, Ziyu
Zhang, Peng
Li, Zhiye
Pei, Xun
Wang, Yonggang
Sui, Binbin
Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
title Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
title_full Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
title_fullStr Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
title_full_unstemmed Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
title_short Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
title_sort hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583377/
https://www.ncbi.nlm.nih.gov/pubmed/37848831
http://dx.doi.org/10.1186/s10194-023-01668-0
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