A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment

BACKGROUND: Long-term drug evaluation heavily relies upon rodent models. Drug discovery methods to reduce animal models in oncology may include three-dimensional (3D) cellular systems that take into account tumor microenvironment (TME) cell types and biomechanical properties. METHODS: In this study...

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Detalles Bibliográficos
Autores principales: De Vlieghere, Elly, Van de Vijver, Koen, Blondeel, Eva, Carpentier, Nathan, Ghobeira, Rouba, Pauwels, Jarne, Riemann, Sebastian, Minsart, Manon, Fieuws, Charlotte, Mestach, Johanna, Baeyens, Ans, De Geyter, Nathalie, Debbaut, Charlotte, Denys, Hannelore, Descamps, Benedicte, Claes, Kathleen, Vral, Anne, Van Dorpe, Jo, Gevaert, Kris, De Geest, Bruno G., Ceelen, Wim, Van Vlierberghe, Sandra, De Wever, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583378/
https://www.ncbi.nlm.nih.gov/pubmed/37853495
http://dx.doi.org/10.1186/s40824-023-00441-3

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