Unveiling the role of GAS41 in cancer progression

GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer development. It serves as a highly promising epigenetic reader, facilitating precise regulation of cell growth and development by recognizing essential histone modifications, including histone acetylation, benzoyl...

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Autores principales: Ji, Kangkang, Li, Li, Liu, Hui, Shen, Yucheng, Jiang, Jian, Zhang, Minglei, Teng, Hongwei, Yan, Xun, Zhang, Yanhua, Cai, Yong, Zhou, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583379/
https://www.ncbi.nlm.nih.gov/pubmed/37853482
http://dx.doi.org/10.1186/s12935-023-03098-z
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author Ji, Kangkang
Li, Li
Liu, Hui
Shen, Yucheng
Jiang, Jian
Zhang, Minglei
Teng, Hongwei
Yan, Xun
Zhang, Yanhua
Cai, Yong
Zhou, Hai
author_facet Ji, Kangkang
Li, Li
Liu, Hui
Shen, Yucheng
Jiang, Jian
Zhang, Minglei
Teng, Hongwei
Yan, Xun
Zhang, Yanhua
Cai, Yong
Zhou, Hai
author_sort Ji, Kangkang
collection PubMed
description GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer development. It serves as a highly promising epigenetic reader, facilitating precise regulation of cell growth and development by recognizing essential histone modifications, including histone acetylation, benzoylation, succinylation, and crotonylation. Functional readouts of these histone modifications often coincide with cancer progression. In addition, GAS41 functions as a novel oncogene, participating in numerous signaling pathways. Here, we summarize the epigenetic functions of GAS41 and its role in the carcinoma progression. Moving forward, elucidating the downstream target oncogenes regulated by GAS41 and the developing small molecule inhibitors based on the distinctive YEATS recognition properties will be pivotal in advancing this research field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-03098-z.
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spelling pubmed-105833792023-10-19 Unveiling the role of GAS41 in cancer progression Ji, Kangkang Li, Li Liu, Hui Shen, Yucheng Jiang, Jian Zhang, Minglei Teng, Hongwei Yan, Xun Zhang, Yanhua Cai, Yong Zhou, Hai Cancer Cell Int Review GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer development. It serves as a highly promising epigenetic reader, facilitating precise regulation of cell growth and development by recognizing essential histone modifications, including histone acetylation, benzoylation, succinylation, and crotonylation. Functional readouts of these histone modifications often coincide with cancer progression. In addition, GAS41 functions as a novel oncogene, participating in numerous signaling pathways. Here, we summarize the epigenetic functions of GAS41 and its role in the carcinoma progression. Moving forward, elucidating the downstream target oncogenes regulated by GAS41 and the developing small molecule inhibitors based on the distinctive YEATS recognition properties will be pivotal in advancing this research field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-03098-z. BioMed Central 2023-10-18 /pmc/articles/PMC10583379/ /pubmed/37853482 http://dx.doi.org/10.1186/s12935-023-03098-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ji, Kangkang
Li, Li
Liu, Hui
Shen, Yucheng
Jiang, Jian
Zhang, Minglei
Teng, Hongwei
Yan, Xun
Zhang, Yanhua
Cai, Yong
Zhou, Hai
Unveiling the role of GAS41 in cancer progression
title Unveiling the role of GAS41 in cancer progression
title_full Unveiling the role of GAS41 in cancer progression
title_fullStr Unveiling the role of GAS41 in cancer progression
title_full_unstemmed Unveiling the role of GAS41 in cancer progression
title_short Unveiling the role of GAS41 in cancer progression
title_sort unveiling the role of gas41 in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583379/
https://www.ncbi.nlm.nih.gov/pubmed/37853482
http://dx.doi.org/10.1186/s12935-023-03098-z
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