KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations

BACKGROUND: Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, efforts to identify the vulnerabilities to overcome these aggressive malignancies have made minimal progress in recent years. Therefore, there is an urgent need to exp...

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Detalles Bibliográficos
Autores principales: Wang, Kaiqing, Gong, Zhicheng, Chen, Yanyan, Zhang, Meimei, Wang, Suzeng, Yao, Surui, Liu, Zhihui, Huang, Zhaohui, Fei, Bojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583429/
https://www.ncbi.nlm.nih.gov/pubmed/37848946
http://dx.doi.org/10.1186/s13148-023-01579-6

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