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Follow the time course of inflammation caused by intraperitoneal administration of multi-wall carbon nanotubes in mice
OBJECTIVE: Understand the progress of inflammation over time caused by multi-walled carbon nanotubes (MWCNT). METHODS: Two types of MWCNTs were administered to C57BL/6N mice via intraperitoneal administration at low and high doses (0.05 and 1.0 mg/mouse, respectively). Inflammation was evaluated unt...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583511/ https://www.ncbi.nlm.nih.gov/pubmed/37846071 http://dx.doi.org/10.1177/03946320231176402 |
Sumario: | OBJECTIVE: Understand the progress of inflammation over time caused by multi-walled carbon nanotubes (MWCNT). METHODS: Two types of MWCNTs were administered to C57BL/6N mice via intraperitoneal administration at low and high doses (0.05 and 1.0 mg/mouse, respectively). Inflammation was evaluated until 6 months after administration based on cytokine levels and pathological observations. The abdominal cavity lavage fluid was collected and analyzed 1 week, 1, 3, and 6 month(s) after administration. IL-6 expression markedly increased 3 months after the administration of high-dose MWCNT-7. RESULTS: Notable inflammation was observed in the groups administered with one of the MWCNT, MWCNT-7. On the other hand, inflammation in another MWCNT-treated group was milder than that in the MWCNT-7-treated group. MWCNT-7 induced pronounced inflammation but did not induce tumor formation during the experimental period. Inflammation reaction is one of the most important biological responses to MWCNT. CONCLUSION: Three months post-exposure becomes a turning point for the harmful effects of the intraperitoneally administered MWCNT-7. |
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