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Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery

Lactate dehydrogenase (LDH, EC.1.1.127) is an important enzyme engaged in the anaerobic metabolism of cells, catalyzing the conversion of pyruvate to lactate and NADH to NAD(+). LDH is a relevant enzyme to investigate structure–function relationships. The present work provides the missing link in ou...

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Detalles Bibliográficos
Autores principales:	Robin, Adeline Y, Brochier-Armanet, Céline, Bertrand, Quentin, Barette, Caroline, Girard, Eric, Madern, Dominique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583557/ https://www.ncbi.nlm.nih.gov/pubmed/37797308 http://dx.doi.org/10.1093/molbev/msad223

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