Cargando…

The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians

The Wolfram syndrome 1 gene (WFS1) is the main causative locus for Wolfram syndrome, an inherited condition characterized by childhood-onset diabetes mellitus, optic atrophy, and deafness. Global genome-wide association studies have listed at least 19 WFS1 variants that are associated with type 2 di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hammad, Maha M., Abu-Farha, Mohamed, Hebbar, Prashantha, Anoop, Emil, Chandy, Betty, Melhem, Motasem, Channanath, Arshad, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse, Abubaker, Jehad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583568/ https://www.ncbi.nlm.nih.gov/pubmed/37859980 http://dx.doi.org/10.3389/fendo.2023.1185956

Ejemplares similares

Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait
por: Rahman, Abdur, et al.
Publicado: (2023)

Generalizability of GWA-Identified Genetic Risk Variants for Metabolic Traits to Populations from the Arabian Peninsula
por: Hebbar, Prashantha, et al.
Publicado: (2021)

FTO Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals
por: Alanbaei, Muath, et al.
Publicado: (2021)

MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort
por: Hammad, Maha M., et al.
Publicado: (2020)

A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations
por: Hebbar, Prashantha, et al.
Publicado: (2019)

Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians
por: Al Madhoun, Ashraf, et al.
Publicado: (2022)

GALNT2 rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level
por: Qaddoumi, Mohammad, et al.
Publicado: (2022)

Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

Relevance between COVID-19 and host genetics of immune response
por: Taher, Ibrahim, et al.
Publicado: (2021)

Distribution of HLA-B Alleles and Haplotypes in Qatari: Recommendation for Establishing Pharmacogenomic Markers Screening for Drug Hypersensitivity
por: Dashti, Mohammed, et al.
Publicado: (2022)

PharmaKU: A Web-Based Tool Aimed at Improving Outreach and Clinical Utility of Pharmacogenomics
por: John, Sumi Elsa, et al.
Publicado: (2021)

Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in Kuwait
por: Dashti, Mohammed, et al.
Publicado: (2021)

Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

ONECUT1 variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts
por: Dashti, Mohammed, et al.
Publicado: (2023)

Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
por: Qaddoumi, Mohammad G., et al.
Publicado: (2020)

LRG1 Associates with Iron Deficiency Anemia Markers in Adolescents
por: Alhammad, Rashed, et al.
Publicado: (2023)

The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19
por: Bosso, Mira, et al.
Publicado: (2020)

The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation
por: Abu-Farha, Mohamed, et al.
Publicado: (2023)

Differentially methylated and expressed genes in familial type 1 diabetes
por: Dashti, Mohammed, et al.
Publicado: (2022)

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

Association of COVID-19 Vaccines ChAdOx1-S and BNT162b2 with Circulating Levels of Coagulation Factors and Antithrombin
por: Hasan, Amal, et al.
Publicado: (2022)

Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant
por: Abu-Farha, Mohamed, et al.
Publicado: (2023)

Increased LRG1 Levels in Overweight and Obese Adolescents and Its Association with Obesity Markers, Including Leptin, Chemerin, and High Sensitivity C-Reactive Protein
por: Alhammad, Rashed, et al.
Publicado: (2022)

Impact of Diabetes in Patients Diagnosed With COVID-19
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics
por: John, Sumi Elsa, et al.
Publicado: (2018)

Frequency of functional exonic single-nucleotide polymorphisms and haplotype distribution in the SLCO1B1 gene across genetic ancestry groups in the Qatari population
por: Dashti, Mohammed, et al.
Publicado: (2022)

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains
por: Haddad, Dania, et al.
Publicado: (2021)

Immunogenicity of BNT162b2 Vaccine in Patients with Inflammatory Bowel Disease on Infliximab Combination Therapy: A Multicenter Prospective Study
por: Shehab, Mohammad, et al.
Publicado: (2021)

ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19
por: Al-Mulla, Fahd, et al.
Publicado: (2021)

Unraveling a fine-scale high genetic heterogeneity and recent continental connections of an Arabian Peninsula population
por: Eaaswarkhanth, Muthukrishnan, et al.
Publicado: (2021)

Serological Response to BNT162b2 and ChAdOx1 nCoV-19 Vaccines in Patients with Inflammatory Bowel Disease on Biologic Therapies
por: Shehab, Mohammad, et al.
Publicado: (2021)

Exploring the Binding Mechanism of NRG1–ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression
por: Marafie, Sulaiman K., et al.
Publicado: (2023)

Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families
por: Hebbar, Prashantha, et al.
Publicado: (2023)

Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery
por: Alterki, Abdulmohsen, et al.
Publicado: (2020)

Immunogenicity of BNT162b2 Vaccine Booster Dose in Patients With Inflammatory Bowel Disease Receiving Infliximab Combination Therapy: A Prospective Observational Study
por: Shehab, Mohammad, et al.
Publicado: (2022)

Kuwaiti population subgroup of nomadic Bedouin ancestry—Whole genome sequence and analysis
por: John, Sumi Elsa, et al.
Publicado: (2014)

Sequence and analysis of a whole genome from Kuwaiti population subgroup of Persian ancestry
por: Thareja, Gaurav, et al.
Publicado: (2015)

Genetic risk variants for metabolic traits in Arab populations
por: Hebbar, Prashantha, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_veu4cn5vqprlfj8sg7frqgq7m9