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The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer

Background: In recent years, several studies have investigated the relationship between platelet to lymphocyte ratio (PLR) and the prognosis of patients with laryngeal cancer, but the results remain controversial. This study aimed to evaluate the prognostic significance of pretreatment PLR in patien...

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Autores principales: Li, Qin, Chen, Mengqi, Xiao, Lamei, Zhao, Huaqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583586/
https://www.ncbi.nlm.nih.gov/pubmed/37859820
http://dx.doi.org/10.7150/jca.87397
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author Li, Qin
Chen, Mengqi
Xiao, Lamei
Zhao, Huaqin
author_facet Li, Qin
Chen, Mengqi
Xiao, Lamei
Zhao, Huaqin
author_sort Li, Qin
collection PubMed
description Background: In recent years, several studies have investigated the relationship between platelet to lymphocyte ratio (PLR) and the prognosis of patients with laryngeal cancer, but the results remain controversial. This study aimed to evaluate the prognostic significance of pretreatment PLR in patients with laryngeal cancer. Methods: Up to July 2023, we searched PubMed, PubMed Central, Web of Science, Embase, CNKI and Wanfang databases to collect relevant articles evaluating the relationship between PLR and the prognosis of laryngeal cancer. The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated using the random effect-model. Results: A total of 14 included studies involving 3220 patients with laryngeal cancer were included. The combined results suggested that elevated PLR was associated with poorer overall survival (HR = 2.21, 95% CI, 1.67 - 2.93, p < 0.001), progression-free survival (HR = 2.54, 95% CI, 1.76-3.66, p < 0.001), recurrence-free survival (HR = 1.87, 95% CI,1.45 - 2.42, p < 0.001), and disease-free survival (HR = 1.46, 95% CI, 1.08-1.98, p < 0.001). Subgroup analysis further confirmed that pretreatment PLR was an independent predictor of OS in laryngeal cancer patients. Conclusion: Higher pretreatment PLR is strongly related to poor prognosis of laryngeal cancer patients. This indicates that PLR has the potential to serve as a valuable biomarker for predicting the prognosis of laryngeal cancer. However, further validations in large prospective cohorts are necessary to confirm its clinical utility and reliability.
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spelling pubmed-105835862023-10-19 The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer Li, Qin Chen, Mengqi Xiao, Lamei Zhao, Huaqin J Cancer Research Paper Background: In recent years, several studies have investigated the relationship between platelet to lymphocyte ratio (PLR) and the prognosis of patients with laryngeal cancer, but the results remain controversial. This study aimed to evaluate the prognostic significance of pretreatment PLR in patients with laryngeal cancer. Methods: Up to July 2023, we searched PubMed, PubMed Central, Web of Science, Embase, CNKI and Wanfang databases to collect relevant articles evaluating the relationship between PLR and the prognosis of laryngeal cancer. The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated using the random effect-model. Results: A total of 14 included studies involving 3220 patients with laryngeal cancer were included. The combined results suggested that elevated PLR was associated with poorer overall survival (HR = 2.21, 95% CI, 1.67 - 2.93, p < 0.001), progression-free survival (HR = 2.54, 95% CI, 1.76-3.66, p < 0.001), recurrence-free survival (HR = 1.87, 95% CI,1.45 - 2.42, p < 0.001), and disease-free survival (HR = 1.46, 95% CI, 1.08-1.98, p < 0.001). Subgroup analysis further confirmed that pretreatment PLR was an independent predictor of OS in laryngeal cancer patients. Conclusion: Higher pretreatment PLR is strongly related to poor prognosis of laryngeal cancer patients. This indicates that PLR has the potential to serve as a valuable biomarker for predicting the prognosis of laryngeal cancer. However, further validations in large prospective cohorts are necessary to confirm its clinical utility and reliability. Ivyspring International Publisher 2023-09-11 /pmc/articles/PMC10583586/ /pubmed/37859820 http://dx.doi.org/10.7150/jca.87397 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Li, Qin
Chen, Mengqi
Xiao, Lamei
Zhao, Huaqin
The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer
title The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer
title_full The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer
title_fullStr The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer
title_full_unstemmed The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer
title_short The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer
title_sort prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583586/
https://www.ncbi.nlm.nih.gov/pubmed/37859820
http://dx.doi.org/10.7150/jca.87397
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