Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections

The clinical relevance of bacteriuria following antibiotic treatment of complicated urinary tract infections in clinical trials remains controversial. We evaluated the impact of urine pharmacokinetics on the timing of recurrent bacteriuria in a recently completed trial that compared oral tebipenem p...

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Detalles Bibliográficos
Autores principales: Melnick, David, Talley, Angela K., Gupta, Vipul K., Critchley, Ian A., Eckburg, Paul B., Hamed, Kamal A., Bhatt, Nivedita, Moore, Gary, Austin, Daren, Rubino, Christopher M., Bhavnani, Sujata M., Ambrose, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583661/
https://www.ncbi.nlm.nih.gov/pubmed/37768311
http://dx.doi.org/10.1128/aac.00535-23
Descripción
Sumario:The clinical relevance of bacteriuria following antibiotic treatment of complicated urinary tract infections in clinical trials remains controversial. We evaluated the impact of urine pharmacokinetics on the timing of recurrent bacteriuria in a recently completed trial that compared oral tebipenem pivoxil hydrobromide to intravenous ertapenem. The urinary clearance and urine dwell time of ertapenem were prolonged relative to tebipenem and were associated with a temporal difference in the repopulation of bladder urine with bacteria following treatment, potentially confounding the assessment of efficacy.

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