Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling

A double ampC (AmpC(G183D)) and ampD (AmpD(H157Y)) genes mutations have been identified by whole genome sequencing in a Pseudomonas aeruginosa (PaS) that became resistant (PaR) in a patient treated by ceftolozane/tazobactam (C/T). To precisely characterize the respective contributions of these mutat...

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Detalles Bibliográficos
Autores principales: Deroche, Luc, Aranzana-Climent, Vincent, Rozenholc, Albane, Prouvensier, Laure, Darnaud, Léa, Grégoire, Nicolas, Marchand, Sandrine, Ploy, Marie-Cécile, François, Bruno, Couet, William, Barraud, Olivier, Buyck, Julien M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583683/
https://www.ncbi.nlm.nih.gov/pubmed/37695298
http://dx.doi.org/10.1128/aac.00480-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583683/
https://www.ncbi.nlm.nih.gov/pubmed/37695298
http://dx.doi.org/10.1128/aac.00480-23

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