CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms

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Multidrug resistance (MDR) transporters such as ATP-Binding Cassette (ABC) and Major Facilitator Superfamily proteins are important mediators of antifungal drug resistance, particularly with respect to azole class drugs. Consequently, identifying molecules that are not susceptible to this mechanism...

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Detalles Bibliográficos
Autores principales: Miron-Ocampo, Aracely, Beattie, Sarah R., Guin, Soumitra, Conway, Thomas, Meyers, Marvin J., Moye-Rowley, W. Scott, Krysan, Damian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583685/
https://www.ncbi.nlm.nih.gov/pubmed/37702508
http://dx.doi.org/10.1128/aac.00567-23
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