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Bronchopulmonary penetration of isavuconazole in lung transplant recipients
Isavuconazole’s (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h resp...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583689/ https://www.ncbi.nlm.nih.gov/pubmed/37787528 http://dx.doi.org/10.1128/aac.00613-23 |
| _version_ | 1785122606465155072 |
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| author | Caballero-Bermejo, Antonio F. Darnaude-Ximénez, Ignacio Aguilar-Pérez, Myriam Gomez-Lopez, Alicia Sancho-López, Aránzazu López García-Gallo, Cristina Díaz Nuevo, Gema Diago-Sempere, Elena Ruiz-Antorán, Belén Avendaño-Solá, Cristina Ussetti-Gil, Piedad |
| author_facet | Caballero-Bermejo, Antonio F. Darnaude-Ximénez, Ignacio Aguilar-Pérez, Myriam Gomez-Lopez, Alicia Sancho-López, Aránzazu López García-Gallo, Cristina Díaz Nuevo, Gema Diago-Sempere, Elena Ruiz-Antorán, Belén Avendaño-Solá, Cristina Ussetti-Gil, Piedad |
| author_sort | Caballero-Bermejo, Antonio F. |
| collection | PubMed |
| description | Isavuconazole’s (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h respectively. Mean concentrations in the epithelial lining fluid were 0.969 (SD 0.895), 2.141 (SD 1.265), and 2.812 (SD 0.693) at the same time points. ISA is a drug with a tolerable safety profile that achieves adequate concentrations in the lung. |
| format | Online Article Text |
| id | pubmed-10583689 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105836892023-10-19 Bronchopulmonary penetration of isavuconazole in lung transplant recipients Caballero-Bermejo, Antonio F. Darnaude-Ximénez, Ignacio Aguilar-Pérez, Myriam Gomez-Lopez, Alicia Sancho-López, Aránzazu López García-Gallo, Cristina Díaz Nuevo, Gema Diago-Sempere, Elena Ruiz-Antorán, Belén Avendaño-Solá, Cristina Ussetti-Gil, Piedad Antimicrob Agents Chemother Pharmacology Isavuconazole’s (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h respectively. Mean concentrations in the epithelial lining fluid were 0.969 (SD 0.895), 2.141 (SD 1.265), and 2.812 (SD 0.693) at the same time points. ISA is a drug with a tolerable safety profile that achieves adequate concentrations in the lung. American Society for Microbiology 2023-10-03 /pmc/articles/PMC10583689/ /pubmed/37787528 http://dx.doi.org/10.1128/aac.00613-23 Text en Copyright © 2023 Caballero-Bermejo et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Pharmacology Caballero-Bermejo, Antonio F. Darnaude-Ximénez, Ignacio Aguilar-Pérez, Myriam Gomez-Lopez, Alicia Sancho-López, Aránzazu López García-Gallo, Cristina Díaz Nuevo, Gema Diago-Sempere, Elena Ruiz-Antorán, Belén Avendaño-Solá, Cristina Ussetti-Gil, Piedad Bronchopulmonary penetration of isavuconazole in lung transplant recipients |
| title | Bronchopulmonary penetration of isavuconazole in lung transplant recipients |
| title_full | Bronchopulmonary penetration of isavuconazole in lung transplant recipients |
| title_fullStr | Bronchopulmonary penetration of isavuconazole in lung transplant recipients |
| title_full_unstemmed | Bronchopulmonary penetration of isavuconazole in lung transplant recipients |
| title_short | Bronchopulmonary penetration of isavuconazole in lung transplant recipients |
| title_sort | bronchopulmonary penetration of isavuconazole in lung transplant recipients |
| topic | Pharmacology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583689/ https://www.ncbi.nlm.nih.gov/pubmed/37787528 http://dx.doi.org/10.1128/aac.00613-23 |
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