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Targeting mitochondrial degradation by chimeric autophagy-tethering compounds

The ability to regulate mitophagy in a living system with small molecules remains a great challenge. We hypothesize that adding fragments specific to the key autophagosome protein LC3 to mitochondria will mimic receptor-mediated mitophagy, thus engaging the autophagy-lysosome pathway to induce mitoc...

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Detalles Bibliográficos
Autores principales:	Liu, Zhenqi, Qin, Geng, Yang, Jie, Wang, Wenjie, Zhang, Wenting, Lu, Boxun, Ren, Jinsong, Qu, Xiaogang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583747/ https://www.ncbi.nlm.nih.gov/pubmed/37860639 http://dx.doi.org/10.1039/d3sc03600f

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