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Hypocretin / Orexin Receptor 1 Knockdown in GABA or Dopamine Neurons in the Ventral Tegmental Area Differentially Impact Mesolimbic Dopamine and Motivation for Cocaine

The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-administration, blocks reinstatement of cocaine seeking, and decre...

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Detalles Bibliográficos
Autores principales:	Black, Emily M., Samels, Shanna B., Xu, Wei, Barson, Jessica R., Bass, Caroline E., Kortagere, Sandhya, España, Rodrigo A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583964/ https://www.ncbi.nlm.nih.gov/pubmed/37854172 http://dx.doi.org/10.1016/j.addicn.2023.100104

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