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Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation
BACKGROUND: Pretransplant therapies such as rituximab and plasmapheresis have led to an increase in ABO-incompatible (ABOi) living donor liver transplantation (LDLT), thus helping to overcome organ shortages. This study evaluated the changes in anti-A/B titers and CD19 levels over time in patients u...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Transplantation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583967/ https://www.ncbi.nlm.nih.gov/pubmed/37694598 http://dx.doi.org/10.4285/kjt.23.0031 |
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author | Hong, Suk Kyun Lee, Kwang-Woong Kim, Jae-Yoon Lee, Jaewon Kim, Jiyoung Choi, Hyun Hwa Hong, Su young Lee, Jeong-Moo Choi, YoungRok Yi, Nam-Joon Suh, Kyung-Suk |
author_facet | Hong, Suk Kyun Lee, Kwang-Woong Kim, Jae-Yoon Lee, Jaewon Kim, Jiyoung Choi, Hyun Hwa Hong, Su young Lee, Jeong-Moo Choi, YoungRok Yi, Nam-Joon Suh, Kyung-Suk |
author_sort | Hong, Suk Kyun |
collection | PubMed |
description | BACKGROUND: Pretransplant therapies such as rituximab and plasmapheresis have led to an increase in ABO-incompatible (ABOi) living donor liver transplantation (LDLT), thus helping to overcome organ shortages. This study evaluated the changes in anti-A/B titers and CD19 levels over time in patients undergoing ABOi LT and aimed to understand the effect of single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FcγR) on rituximab therapy. METHODS: Two SNPs of FCGR2A (131H/R) and FCGR3A (158F/V) were identified. The clinical data on 44 patients who underwent ABOi LDLT between May 2019 and October 2021 at Seoul National University Hospital were reviewed retrospectively. RESULTS: Following desensitization with rituximab and subsequent LDLT, the anti-A/B titer recovered within 1 week, but decreased thereafter. The CD19 level increased at 3 months after LT. The genotyping data for FCGR3A (158F/V) indicated that two patients had the V/V genotype, and 42 had the F/V genotype. In the genotyping data for FCGR2A (131H/R), 21 patients had the H/H genotype, three had the R/R genotype, and 20 had the H/R genotype. However, there were no significant differences in anti-A/B and CD19 levels, bacteremia rates, T cell-mediated rejection, antibody-mediated rejection, or the survival rate among the FCGR2A types. CONCLUSIONS: There were significant changes in the anti-A/B titers and CD19 levels over time in each patient after ABOi LDLT. The difference in outcomes following LT according to the FcγR SNP type for rituximab was unclear. Further studies with larger sample sizes are needed to confirm the effect of FcγR SNPs on rituximab therapy. |
format | Online Article Text |
id | pubmed-10583967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Society for Transplantation |
record_format | MEDLINE/PubMed |
spelling | pubmed-105839672023-10-19 Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation Hong, Suk Kyun Lee, Kwang-Woong Kim, Jae-Yoon Lee, Jaewon Kim, Jiyoung Choi, Hyun Hwa Hong, Su young Lee, Jeong-Moo Choi, YoungRok Yi, Nam-Joon Suh, Kyung-Suk Korean J Transplant Original Article BACKGROUND: Pretransplant therapies such as rituximab and plasmapheresis have led to an increase in ABO-incompatible (ABOi) living donor liver transplantation (LDLT), thus helping to overcome organ shortages. This study evaluated the changes in anti-A/B titers and CD19 levels over time in patients undergoing ABOi LT and aimed to understand the effect of single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FcγR) on rituximab therapy. METHODS: Two SNPs of FCGR2A (131H/R) and FCGR3A (158F/V) were identified. The clinical data on 44 patients who underwent ABOi LDLT between May 2019 and October 2021 at Seoul National University Hospital were reviewed retrospectively. RESULTS: Following desensitization with rituximab and subsequent LDLT, the anti-A/B titer recovered within 1 week, but decreased thereafter. The CD19 level increased at 3 months after LT. The genotyping data for FCGR3A (158F/V) indicated that two patients had the V/V genotype, and 42 had the F/V genotype. In the genotyping data for FCGR2A (131H/R), 21 patients had the H/H genotype, three had the R/R genotype, and 20 had the H/R genotype. However, there were no significant differences in anti-A/B and CD19 levels, bacteremia rates, T cell-mediated rejection, antibody-mediated rejection, or the survival rate among the FCGR2A types. CONCLUSIONS: There were significant changes in the anti-A/B titers and CD19 levels over time in each patient after ABOi LDLT. The difference in outcomes following LT according to the FcγR SNP type for rituximab was unclear. Further studies with larger sample sizes are needed to confirm the effect of FcγR SNPs on rituximab therapy. The Korean Society for Transplantation 2023-09-30 2023-09-11 /pmc/articles/PMC10583967/ /pubmed/37694598 http://dx.doi.org/10.4285/kjt.23.0031 Text en Copyright © 2023 The Korean Society for Transplantation https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hong, Suk Kyun Lee, Kwang-Woong Kim, Jae-Yoon Lee, Jaewon Kim, Jiyoung Choi, Hyun Hwa Hong, Su young Lee, Jeong-Moo Choi, YoungRok Yi, Nam-Joon Suh, Kyung-Suk Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation |
title | Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation |
title_full | Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation |
title_fullStr | Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation |
title_full_unstemmed | Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation |
title_short | Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation |
title_sort | factors associated with rituximab-mediated b cell depletion in abo-incompatible adult living donor liver transplantation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583967/ https://www.ncbi.nlm.nih.gov/pubmed/37694598 http://dx.doi.org/10.4285/kjt.23.0031 |
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