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The role of inflammation in autoimmune disease: a therapeutic target
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs are produced by the immune system’s misidentification of self-antigens, seemingly caused by excessive immune function, but in fact they are the result of reduced accuracy due to the decli...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584158/ https://www.ncbi.nlm.nih.gov/pubmed/37859999 http://dx.doi.org/10.3389/fimmu.2023.1267091 |
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author | Xiang, Yu Zhang, Mingxue Jiang, Die Su, Qian Shi, Jianyou |
author_facet | Xiang, Yu Zhang, Mingxue Jiang, Die Su, Qian Shi, Jianyou |
author_sort | Xiang, Yu |
collection | PubMed |
description | Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs are produced by the immune system’s misidentification of self-antigens, seemingly caused by excessive immune function, but in fact they are the result of reduced accuracy due to the decline in immune system function, which cannot clearly identify foreign invaders and self-antigens, thus issuing false attacks, and eventually leading to disease. The occurrence of AIDs is often accompanied by the emergence of inflammation, and inflammatory mediators (inflammatory factors, inflammasomes) play an important role in the pathogenesis of AIDs, which mediate the immune process by affecting innate cells (such as macrophages) and adaptive cells (such as T and B cells), and ultimately promote the occurrence of autoimmune responses, so targeting inflammatory mediators/pathways is one of emerging the treatment strategies of AIDs. This review will briefly describe the role of inflammation in the pathogenesis of different AIDs, and give a rough introduction to inhibitors targeting inflammatory factors, hoping to have reference significance for subsequent treatment options for AIDs. |
format | Online Article Text |
id | pubmed-10584158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105841582023-10-19 The role of inflammation in autoimmune disease: a therapeutic target Xiang, Yu Zhang, Mingxue Jiang, Die Su, Qian Shi, Jianyou Front Immunol Immunology Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs are produced by the immune system’s misidentification of self-antigens, seemingly caused by excessive immune function, but in fact they are the result of reduced accuracy due to the decline in immune system function, which cannot clearly identify foreign invaders and self-antigens, thus issuing false attacks, and eventually leading to disease. The occurrence of AIDs is often accompanied by the emergence of inflammation, and inflammatory mediators (inflammatory factors, inflammasomes) play an important role in the pathogenesis of AIDs, which mediate the immune process by affecting innate cells (such as macrophages) and adaptive cells (such as T and B cells), and ultimately promote the occurrence of autoimmune responses, so targeting inflammatory mediators/pathways is one of emerging the treatment strategies of AIDs. This review will briefly describe the role of inflammation in the pathogenesis of different AIDs, and give a rough introduction to inhibitors targeting inflammatory factors, hoping to have reference significance for subsequent treatment options for AIDs. Frontiers Media S.A. 2023-10-04 /pmc/articles/PMC10584158/ /pubmed/37859999 http://dx.doi.org/10.3389/fimmu.2023.1267091 Text en Copyright © 2023 Xiang, Zhang, Jiang, Su and Shi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Xiang, Yu Zhang, Mingxue Jiang, Die Su, Qian Shi, Jianyou The role of inflammation in autoimmune disease: a therapeutic target |
title | The role of inflammation in autoimmune disease: a therapeutic target |
title_full | The role of inflammation in autoimmune disease: a therapeutic target |
title_fullStr | The role of inflammation in autoimmune disease: a therapeutic target |
title_full_unstemmed | The role of inflammation in autoimmune disease: a therapeutic target |
title_short | The role of inflammation in autoimmune disease: a therapeutic target |
title_sort | role of inflammation in autoimmune disease: a therapeutic target |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584158/ https://www.ncbi.nlm.nih.gov/pubmed/37859999 http://dx.doi.org/10.3389/fimmu.2023.1267091 |
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