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Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain

Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria f...

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Autores principales: Ma, Qingle, Yao, Chenlu, Wu, Yi, Wang, Heng, Fan, Qin, Yang, Qianyu, Xu, Jialu, Dai, Huaxing, Zhang, Yue, Xu, Fang, Lu, Ting, Dowling, Jennifer K., Wang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584344/
https://www.ncbi.nlm.nih.gov/pubmed/37851811
http://dx.doi.org/10.1126/sciadv.adi0699
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author Ma, Qingle
Yao, Chenlu
Wu, Yi
Wang, Heng
Fan, Qin
Yang, Qianyu
Xu, Jialu
Dai, Huaxing
Zhang, Yue
Xu, Fang
Lu, Ting
Dowling, Jennifer K.
Wang, Chao
author_facet Ma, Qingle
Yao, Chenlu
Wu, Yi
Wang, Heng
Fan, Qin
Yang, Qianyu
Xu, Jialu
Dai, Huaxing
Zhang, Yue
Xu, Fang
Lu, Ting
Dowling, Jennifer K.
Wang, Chao
author_sort Ma, Qingle
collection PubMed
description Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria from the lung to the brain during pneumonia. Using principal components analysis, similarities were found between the brain’s flora species and those of the lungs, indicating that the bacteria detected in the brain may originate from the lungs. We also observed impairment of both the lung-blood and brain-blood barriers, allowing endogenous lung bacteria to invade the brain during pneumonia. An elevated microglia and astrocyte activation signature via bacterial infection–related pathways was observed, indicating a bacterial-induced disruption of brain homeostasis. Collectively, we identify endogenous lung bacteria that play a role in altering brain homeostasis, which provides insight into the mechanism of neurological syndromes after severe pneumonia.
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spelling pubmed-105843442023-10-19 Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain Ma, Qingle Yao, Chenlu Wu, Yi Wang, Heng Fan, Qin Yang, Qianyu Xu, Jialu Dai, Huaxing Zhang, Yue Xu, Fang Lu, Ting Dowling, Jennifer K. Wang, Chao Sci Adv Biomedicine and Life Sciences Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria from the lung to the brain during pneumonia. Using principal components analysis, similarities were found between the brain’s flora species and those of the lungs, indicating that the bacteria detected in the brain may originate from the lungs. We also observed impairment of both the lung-blood and brain-blood barriers, allowing endogenous lung bacteria to invade the brain during pneumonia. An elevated microglia and astrocyte activation signature via bacterial infection–related pathways was observed, indicating a bacterial-induced disruption of brain homeostasis. Collectively, we identify endogenous lung bacteria that play a role in altering brain homeostasis, which provides insight into the mechanism of neurological syndromes after severe pneumonia. American Association for the Advancement of Science 2023-10-18 /pmc/articles/PMC10584344/ /pubmed/37851811 http://dx.doi.org/10.1126/sciadv.adi0699 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Ma, Qingle
Yao, Chenlu
Wu, Yi
Wang, Heng
Fan, Qin
Yang, Qianyu
Xu, Jialu
Dai, Huaxing
Zhang, Yue
Xu, Fang
Lu, Ting
Dowling, Jennifer K.
Wang, Chao
Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
title Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
title_full Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
title_fullStr Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
title_full_unstemmed Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
title_short Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
title_sort neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584344/
https://www.ncbi.nlm.nih.gov/pubmed/37851811
http://dx.doi.org/10.1126/sciadv.adi0699
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