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Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain
Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria f...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584344/ https://www.ncbi.nlm.nih.gov/pubmed/37851811 http://dx.doi.org/10.1126/sciadv.adi0699 |
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author | Ma, Qingle Yao, Chenlu Wu, Yi Wang, Heng Fan, Qin Yang, Qianyu Xu, Jialu Dai, Huaxing Zhang, Yue Xu, Fang Lu, Ting Dowling, Jennifer K. Wang, Chao |
author_facet | Ma, Qingle Yao, Chenlu Wu, Yi Wang, Heng Fan, Qin Yang, Qianyu Xu, Jialu Dai, Huaxing Zhang, Yue Xu, Fang Lu, Ting Dowling, Jennifer K. Wang, Chao |
author_sort | Ma, Qingle |
collection | PubMed |
description | Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria from the lung to the brain during pneumonia. Using principal components analysis, similarities were found between the brain’s flora species and those of the lungs, indicating that the bacteria detected in the brain may originate from the lungs. We also observed impairment of both the lung-blood and brain-blood barriers, allowing endogenous lung bacteria to invade the brain during pneumonia. An elevated microglia and astrocyte activation signature via bacterial infection–related pathways was observed, indicating a bacterial-induced disruption of brain homeostasis. Collectively, we identify endogenous lung bacteria that play a role in altering brain homeostasis, which provides insight into the mechanism of neurological syndromes after severe pneumonia. |
format | Online Article Text |
id | pubmed-10584344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105843442023-10-19 Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain Ma, Qingle Yao, Chenlu Wu, Yi Wang, Heng Fan, Qin Yang, Qianyu Xu, Jialu Dai, Huaxing Zhang, Yue Xu, Fang Lu, Ting Dowling, Jennifer K. Wang, Chao Sci Adv Biomedicine and Life Sciences Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria from the lung to the brain during pneumonia. Using principal components analysis, similarities were found between the brain’s flora species and those of the lungs, indicating that the bacteria detected in the brain may originate from the lungs. We also observed impairment of both the lung-blood and brain-blood barriers, allowing endogenous lung bacteria to invade the brain during pneumonia. An elevated microglia and astrocyte activation signature via bacterial infection–related pathways was observed, indicating a bacterial-induced disruption of brain homeostasis. Collectively, we identify endogenous lung bacteria that play a role in altering brain homeostasis, which provides insight into the mechanism of neurological syndromes after severe pneumonia. American Association for the Advancement of Science 2023-10-18 /pmc/articles/PMC10584344/ /pubmed/37851811 http://dx.doi.org/10.1126/sciadv.adi0699 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Ma, Qingle Yao, Chenlu Wu, Yi Wang, Heng Fan, Qin Yang, Qianyu Xu, Jialu Dai, Huaxing Zhang, Yue Xu, Fang Lu, Ting Dowling, Jennifer K. Wang, Chao Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain |
title | Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain |
title_full | Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain |
title_fullStr | Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain |
title_full_unstemmed | Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain |
title_short | Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain |
title_sort | neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584344/ https://www.ncbi.nlm.nih.gov/pubmed/37851811 http://dx.doi.org/10.1126/sciadv.adi0699 |
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