Cargando…

Molecular genetic aberrations in the pathogenesis of multiple myeloma

Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is a complex, progressive, and highly heterogeneous malignancy, which occurs via a multistep transformation process involving primary and second...

Descripción completa

Detalles Bibliográficos
Autores principales: Bong, Ivyna Pau Ni, Esa, Ezalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584387/
https://www.ncbi.nlm.nih.gov/pubmed/37860676
http://dx.doi.org/10.2478/abm-2023-0056
_version_ 1785122727481311232
author Bong, Ivyna Pau Ni
Esa, Ezalia
author_facet Bong, Ivyna Pau Ni
Esa, Ezalia
author_sort Bong, Ivyna Pau Ni
collection PubMed
description Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is a complex, progressive, and highly heterogeneous malignancy, which occurs via a multistep transformation process involving primary and secondary oncogenic events. Recent advances in molecular techniques have further expanded our understanding of the mutational landscape, clonal composition, and dynamic evolution patterns of MM. The first part of this review describes the key oncogenic events involved in the initiation and progression of MM, together with their prognostic impact. The latter part highlights the most prominent findings concerning genomic aberrations promoted by gene expression profiling (GEP) and next-generation sequencing (NGS) in MM. This review provides a concise understanding of the molecular pathogenesis of the MM genome and the importance of adopting emerging molecular technology in future clinical management of MM.
format Online
Article
Text
id pubmed-10584387
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Sciendo
record_format MEDLINE/PubMed
spelling pubmed-105843872023-10-19 Molecular genetic aberrations in the pathogenesis of multiple myeloma Bong, Ivyna Pau Ni Esa, Ezalia Asian Biomed (Res Rev News) Review Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is a complex, progressive, and highly heterogeneous malignancy, which occurs via a multistep transformation process involving primary and secondary oncogenic events. Recent advances in molecular techniques have further expanded our understanding of the mutational landscape, clonal composition, and dynamic evolution patterns of MM. The first part of this review describes the key oncogenic events involved in the initiation and progression of MM, together with their prognostic impact. The latter part highlights the most prominent findings concerning genomic aberrations promoted by gene expression profiling (GEP) and next-generation sequencing (NGS) in MM. This review provides a concise understanding of the molecular pathogenesis of the MM genome and the importance of adopting emerging molecular technology in future clinical management of MM. Sciendo 2023-10-18 /pmc/articles/PMC10584387/ /pubmed/37860676 http://dx.doi.org/10.2478/abm-2023-0056 Text en © 2023 Ivyna Pau Ni Bong et al., published by Sciendo https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Review
Bong, Ivyna Pau Ni
Esa, Ezalia
Molecular genetic aberrations in the pathogenesis of multiple myeloma
title Molecular genetic aberrations in the pathogenesis of multiple myeloma
title_full Molecular genetic aberrations in the pathogenesis of multiple myeloma
title_fullStr Molecular genetic aberrations in the pathogenesis of multiple myeloma
title_full_unstemmed Molecular genetic aberrations in the pathogenesis of multiple myeloma
title_short Molecular genetic aberrations in the pathogenesis of multiple myeloma
title_sort molecular genetic aberrations in the pathogenesis of multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584387/
https://www.ncbi.nlm.nih.gov/pubmed/37860676
http://dx.doi.org/10.2478/abm-2023-0056
work_keys_str_mv AT bongivynapauni moleculargeneticaberrationsinthepathogenesisofmultiplemyeloma
AT esaezalia moleculargeneticaberrationsinthepathogenesisofmultiplemyeloma