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Nanoparticle-mediated cancer cell therapy: basic science to clinical applications

Every sixth person in the world dies due to cancer, making it the second leading severe cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 million deaths in 2020. The most common types of cancers reported have been breast (lung, colon and rectum, prostate cases)...

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Autores principales: Verma, Jaya, Warsame, Caaisha, Seenivasagam, Rajkumar Kottayasamy, Katiyar, Nirmal Kumar, Aleem, Eiman, Goel, Saurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584728/
https://www.ncbi.nlm.nih.gov/pubmed/36826760
http://dx.doi.org/10.1007/s10555-023-10086-2
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author Verma, Jaya
Warsame, Caaisha
Seenivasagam, Rajkumar Kottayasamy
Katiyar, Nirmal Kumar
Aleem, Eiman
Goel, Saurav
author_facet Verma, Jaya
Warsame, Caaisha
Seenivasagam, Rajkumar Kottayasamy
Katiyar, Nirmal Kumar
Aleem, Eiman
Goel, Saurav
author_sort Verma, Jaya
collection PubMed
description Every sixth person in the world dies due to cancer, making it the second leading severe cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 million deaths in 2020. The most common types of cancers reported have been breast (lung, colon and rectum, prostate cases), skin (non-melanoma) and stomach. In addition to surgery, the most widely used traditional types of anti-cancer treatment are radio- and chemotherapy. However, these do not distinguish between normal and malignant cells. Additional treatment methods have evolved over time for early detection and targeted therapy of cancer. However, each method has its limitations and the associated treatment costs are quite high with adverse effects on the quality of life of patients. Use of individual atoms or a cluster of atoms (nanoparticles) can cause a paradigm shift by virtue of providing point of sight sensing and diagnosis of cancer. Nanoparticles (1–100 nm in size) are 1000 times smaller in size than the human cell and endowed with safer relocation capability to attack mechanically and chemically at a precise location which is one avenue that can be used to destroy cancer cells precisely. This review summarises the extant understanding and the work done in this area to pave the way for physicians to accelerate the use of hybrid mode of treatments by leveraging the use of various nanoparticles.
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spelling pubmed-105847282023-10-20 Nanoparticle-mediated cancer cell therapy: basic science to clinical applications Verma, Jaya Warsame, Caaisha Seenivasagam, Rajkumar Kottayasamy Katiyar, Nirmal Kumar Aleem, Eiman Goel, Saurav Cancer Metastasis Rev Article Every sixth person in the world dies due to cancer, making it the second leading severe cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 million deaths in 2020. The most common types of cancers reported have been breast (lung, colon and rectum, prostate cases), skin (non-melanoma) and stomach. In addition to surgery, the most widely used traditional types of anti-cancer treatment are radio- and chemotherapy. However, these do not distinguish between normal and malignant cells. Additional treatment methods have evolved over time for early detection and targeted therapy of cancer. However, each method has its limitations and the associated treatment costs are quite high with adverse effects on the quality of life of patients. Use of individual atoms or a cluster of atoms (nanoparticles) can cause a paradigm shift by virtue of providing point of sight sensing and diagnosis of cancer. Nanoparticles (1–100 nm in size) are 1000 times smaller in size than the human cell and endowed with safer relocation capability to attack mechanically and chemically at a precise location which is one avenue that can be used to destroy cancer cells precisely. This review summarises the extant understanding and the work done in this area to pave the way for physicians to accelerate the use of hybrid mode of treatments by leveraging the use of various nanoparticles. Springer US 2023-02-24 2023 /pmc/articles/PMC10584728/ /pubmed/36826760 http://dx.doi.org/10.1007/s10555-023-10086-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Verma, Jaya
Warsame, Caaisha
Seenivasagam, Rajkumar Kottayasamy
Katiyar, Nirmal Kumar
Aleem, Eiman
Goel, Saurav
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
title Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
title_full Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
title_fullStr Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
title_full_unstemmed Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
title_short Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
title_sort nanoparticle-mediated cancer cell therapy: basic science to clinical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584728/
https://www.ncbi.nlm.nih.gov/pubmed/36826760
http://dx.doi.org/10.1007/s10555-023-10086-2
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