Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain

BACKGROUND: Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recently, the involvement of RIPK1 in the pathophysiology of Alzheimer’s disease (AD) has been reported; RIPK1 is involved in microglia’s phenotypic transit...

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Detalles Bibliográficos
Autores principales: Ikenuma, Hiroshi, Ogata, Aya, Koyama, Hiroko, Ji, Bin, Ishii, Hideki, Yamada, Takashi, Abe, Junichiro, Seki, Chie, Nagai, Yuji, Ichise, Masanori, Minamimoto, Takafumi, Higuchi, Makoto, Zhang, Ming-Rong, Kato, Takashi, Ito, Kengo, Suzuki, Masaaki, Kimura, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584749/
https://www.ncbi.nlm.nih.gov/pubmed/37853253
http://dx.doi.org/10.1186/s41181-023-00217-z

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