Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis

Diabetes is known to increase the risk of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Here we treat male STAM (STelic Animal Model) mice, which develop diabetes, NASH and HCC associated with dysbiosis upon low-dose streptozotocin and high-fat diet (HFD), with insulin or p...

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Detalles Bibliográficos
Autores principales: Soeda, Kotaro, Sasako, Takayoshi, Enooku, Kenichiro, Kubota, Naoto, Kobayashi, Naoki, Ikushima, Yoshiko Matsumoto, Awazawa, Motoharu, Bouchi, Ryotaro, Toda, Gotaro, Yamada, Tomoharu, Nakatsuka, Takuma, Tateishi, Ryosuke, Kakiuchi, Miwako, Yamamoto, Shogo, Tatsuno, Kenji, Atarashi, Koji, Suda, Wataru, Honda, Kenya, Aburatani, Hiroyuki, Yamauchi, Toshimasa, Fujishiro, Mitsuhiro, Noda, Tetsuo, Koike, Kazuhiko, Kadowaki, Takashi, Ueki, Kohjiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584811/
https://www.ncbi.nlm.nih.gov/pubmed/37852976
http://dx.doi.org/10.1038/s41467-023-42334-y

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